Literature DB >> 12000303

Conversion of carbamates to amidosulfones and amides. Synthesis of the [14C]-labeled antiobesity agent Ro23-7637.

James D White1, Paul R Blakemore, Selena Milicevic, Satish C Choudhry, Joseph Cupano, Lucia Serico.   

Abstract

[reaction: see text] Carbamates of primary and secondary amines react with the dianion of methyl phenyl sulfone to yield amidosulfones. Alylation of the amidosulfone followed by reductive removal of the sulfonyl residue gives an amide.

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Year:  2002        PMID： 12000303     DOI： 10.1021/ol020062p

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Chiral oxazolidinones as electrophiles: Intramolecular cyclization reactions with carbanions and preparation of functionalized lactams.

Authors:  Sarah Gibson; Hollie K Jacobs; Aravamudan S Gopalan
Journal:  Tetrahedron Lett       Date:  2011-02-23       Impact factor: 2.415

2.  Reactions of N-benzyloxycarbamate derivatives with stabilized carbon nucleophiles: a new synthetic approach to polyhydroxamic acids and other hydroxamate-containing mixed ligand systems.

Authors:  Yuan Liu; Hollie K Jacobs; Aravamudan S Gopalan
Journal:  J Org Chem       Date:  2009-01-16       Impact factor: 4.354
  2 in total

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