Literature DB >> 11998704

Immunity to Onchocerca spp. in animal hosts.

David Abraham1, Richard Lucius, Alexander J Trees.   

Abstract

This review summarizes research using Onchocerca spp. in chimpanzees, cattle and mice to gain insight into the protective immune response to the filarial worm Onchocerca volvulus in humans. In addition, Acanthocheilonema viteae has been evaluated as a surrogate filarial worm for studying immunity to the infection. Immune mechanisms controlling these infections are described and initial success using recombinant antigen vaccines in these models is reviewed.

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Year:  2002        PMID： 11998704     DOI： 10.1016/s1471-4922(02)02245-6

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  11 in total

1.  Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model.

Authors:  Jessica A Hess; Bin Zhan; Sandra Bonne-Année; Jessica M Deckman; Maria Elena Bottazzi; Peter J Hotez; Thomas R Klei; Sara Lustigman; David Abraham
Journal:  Int J Parasitol       Date:  2014-06-05       Impact factor: 3.981

2.  Evaluation of an OV-16 IgG4 Enzyme-Linked Immunosorbent Assay in Humans and Its Application to Determine the Dynamics of Antibody Responses in a Non-Human Primate Model of Onchocerca volvulus Infection.

Authors:  Vitaliano A Cama; Circe McDonald; Alice Arcury-Quandt; Mark Eberhard; M Harley Jenks; Jared Smith; Sindew M Feleke; Francisca Abanyie; Lakwo Thomson; Ryan E Wiegand; Paul T Cantey
Journal:  Am J Trop Med Hyg       Date:  2018-10       Impact factor: 2.345

3.  Rate of elimination of Wolbachia pipientis by doxycycline in vitro increases following drug withdrawal.

Authors:  Benjamin L Makepeace; Lisa Rodgers; Alexander J Trees
Journal:  Antimicrob Agents Chemother       Date:  2006-03       Impact factor: 5.191

4.  Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae.

Authors:  David Abraham; Ofra Leon; Silvia Schnyder-Candrian; Chun Chi Wang; Ann Marie Galioto; Laura A Kerepesi; James J Lee; Sara Lustigman
Journal:  Infect Immun       Date:  2004-02       Impact factor: 3.441

Review 5.  A research agenda for helminth diseases of humans: basic research and enabling technologies to support control and elimination of helminthiases.

Authors:  Sara Lustigman; Peter Geldhof; Warwick N Grant; Mike Y Osei-Atweneboana; Banchob Sripa; María-Gloria Basáñez
Journal:  PLoS Negl Trop Dis       Date:  2012-04-24

Review 6.  Examining the role of macrolides and host immunity in combatting filarial parasites.

Authors:  Doug S Carithers
Journal:  Parasit Vectors       Date:  2017-04-14       Impact factor: 3.876

7.  Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum.

Authors:  John B Patton; Sasisekhar Bennuru; Mark L Eberhard; Jessica A Hess; April Torigian; Sara Lustigman; Thomas B Nutman; David Abraham
Journal:  PLoS Negl Trop Dis       Date:  2018-12-12

8.  In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases.

Authors:  Robert Adamu Shey; Stephen Mbigha Ghogomu; Kevin Kum Esoh; Neba Derrick Nebangwa; Cabirou Mounchili Shintouo; Nkemngo Francis Nongley; Bertha Fru Asa; Ferdinand Njume Ngale; Luc Vanhamme; Jacob Souopgui
Journal:  Sci Rep       Date:  2019-03-13       Impact factor: 4.379

Review 9.  Of mice, cattle, and humans: the immunology and treatment of river blindness.

Authors:  Judith E Allen; Ohene Adjei; Odile Bain; Achim Hoerauf; Wolfgang H Hoffmann; Benjamin L Makepeace; Hartwig Schulz-Key; Vincent N Tanya; Alexander J Trees; Samuel Wanji; David W Taylor
Journal:  PLoS Negl Trop Dis       Date:  2008-04-30

10.  The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice.

Authors:  Jessica A Hess; Bin Zhan; April R Torigian; John B Patton; Nikolai Petrovsky; Tingting Zhan; Maria Elena Bottazzi; Peter J Hotez; Thomas R Klei; Sara Lustigman; David Abraham
Journal:  PLoS Negl Trop Dis       Date:  2016-07-07
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