Literature DB >> 11997749

[The behavioral disorders in epilepsy].

C Dravet1.   

Abstract

The behavioral disorders are more frequent in the epilepsy patients, children and adults, than in the general population. They have been extensively studied by numerous authors, as well as the underlying various factors. These factors are neurobiological and psychological. From the neurobiological point of view, the importance of the brain damages, their nature, their topography, their lateralization, their date of occurrence during the development have been underlined. Specific personality and behavior features have been linked to the temporal localization of the epilepsy, but many controversies continue about this topic and a behavioral temporal syndrome is not proven. The frontal epilepsies are also responsible for psychological and behavioral disturbances. The epilepsy per se is an etiologic factor, through the ictal events and the interictal changes in the neuronal functioning. One example is that of the endogenous production of opioïd substances during the seizures. However the organic factors cannot be dissociated from the psychological ones. The neuropsychological deficits are significantly linked to the appearance of behavioral disorders in children. The stigma stuck to the epilepsy and the imprevisible character of the seizures have a deep resounding upon the subject, his family and his environment. The pharmacological medications are useful for the depressive and psychotic episodes, but have little efficacy on the character disorders, the aggressiveness and the psychogenic seizures. They need a careful assessment of the situation and a strict super vision of the seizure number (risk of worsening) and of the pharmacocinetic interactions. A comprehensive, social and psychological management of the epilepsy patients is always indicated, knowing that every person is unique and has to be understood and helped in his singularity.

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Year:  2002        PMID: 11997749

Source DB:  PubMed          Journal:  Rev Neurol (Paris)        ISSN: 0035-3787            Impact factor:   2.607


  4 in total

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Authors:  Lily Paemka; Vinit B Mahajan; Jessica M Skeie; Levi P Sowers; Salleh N Ehaideb; Pedro Gonzalez-Alegre; Toshikuni Sasaoka; Hirotaka Tao; Asuka Miyagi; Naoto Ueno; Keizo Takao; Tsuyoshi Miyakawa; Shu Wu; Benjamin W Darbro; Polly J Ferguson; Andrew A Pieper; Jeremiah K Britt; John A Wemmie; Danielle S Rudd; Thomas Wassink; Hatem El-Shanti; Heather C Mefford; Gemma L Carvill; J Robert Manak; Alexander G Bassuk
Journal:  PLoS One       Date:  2013-12-03       Impact factor: 3.240

2.  SYN2 is an autism predisposing gene: loss-of-function mutations alter synaptic vesicle cycling and axon outgrowth.

Authors:  Anna Corradi; Manuela Fadda; Amélie Piton; Lysanne Patry; Antonella Marte; Pia Rossi; Maxime Cadieux-Dion; Julie Gauthier; Line Lapointe; Laurent Mottron; Flavia Valtorta; Guy A Rouleau; Anna Fassio; Fabio Benfenati; Patrick Cossette
Journal:  Hum Mol Genet       Date:  2013-08-15       Impact factor: 6.150

3.  Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.

Authors:  Gabriele Lignani; Andrea Raimondi; Enrico Ferrea; Anna Rocchi; Francesco Paonessa; Fabrizia Cesca; Marta Orlando; Tatiana Tkatch; Flavia Valtorta; Patrick Cossette; Pietro Baldelli; Fabio Benfenati
Journal:  Hum Mol Genet       Date:  2013-02-12       Impact factor: 6.150

4.  Autism-related behavioral abnormalities in synapsin knockout mice.

Authors:  Barbara Greco; Francesca Managò; Valter Tucci; Hung-Teh Kao; Flavia Valtorta; Fabio Benfenati
Journal:  Behav Brain Res       Date:  2012-12-29       Impact factor: 3.332

  4 in total

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