Literature DB >> 11997007

Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease.

Scott B Vafai1, Jeffry B Stock.   

Abstract

Tau hyperphosphorylation is a central event in the development of Alzheimer's Disease (AD). Protein phosphatase 2A (PP2A) heterotrimer formation is necessary for efficient dephosphorylation of the tau protein. S-Adenosylmethionine-dependent carboxyl methylation is essential for the assembly of PP2A heterotrimers. Epidemiological evidence indicates that elevated plasma homocysteine is an independent risk factor for AD. Homocysteine is a key intermediate in the methyl cycle and elevated plasma homocysteine results in a global decrease in cellular methylation. We propose that the PP2A methylation system is the link relating elevated plasma homocysteine to AD.

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Year:  2002        PMID： 11997007     DOI： 10.1016/s0014-5793(02)02702-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  26 in total

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