Literature DB >> 11996067

Correction of count losses due to deadtime on a DST-XLi (SmVi-GE) camera during dosimetric studies in patients injected with iodine-131.

G Delpon1, L Ferrer, A Lisbona, M Bardiès.   

Abstract

In dosimetric studies performed after therapeutic injection, it is essential to correct count losses due to deadtime on the gamma camera. This note describes four deadtime correction methods, one based on the use of a standard source without preliminary calibration, and three requiring specific calibration and based on the count rate observed in different spectrometric windows (20%, 20% plus a lower energy window and the full spectrum of 50-750 keV). Experiments were conducted on a phantom at increasingly higher count rates to check correction accuracy with the different methods. The error was less than +7% with a standard source, whereas count-rate-based methods gave more accurate results. On the assumption that the model was paralysable, preliminary calibration allowed an observed count rate curve to be plotted as a function of the real count rate. The use of the full spectrum led to a 3.0% underestimation for the highest activity imaged. As count losses depend on photon flux independent of energy, the use of the full spectrum during measurement allowed scatter conditions to be taken into account. A protocol was developed to apply this correction method to whole-body acquisitions.

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Year:  2002        PMID: 11996067     DOI: 10.1088/0031-9155/47/7/402

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   3.609


  5 in total

1.  MIRD pamphlet No. 23: quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy.

Authors:  Yuni K Dewaraja; Eric C Frey; George Sgouros; A Bertrand Brill; Peter Roberson; Pat B Zanzonico; Michael Ljungberg
Journal:  J Nucl Med       Date:  2012-06-28       Impact factor: 10.057

2.  A gamma camera count rate saturation correction method for whole-body planar imaging.

Authors:  Robert F Hobbs; Sébastien Baechler; Srinivasan Senthamizhchelvan; Andrew R Prideaux; Caroline E Esaias; Melvin Reinhardt; Eric C Frey; David M Loeb; George Sgouros
Journal:  Phys Med Biol       Date:  2010-01-14       Impact factor: 3.609

3.  Prediction of therapy tumor-absorbed dose estimates in I-131 radioimmunotherapy using tracer data via a mixed-model fit to time activity.

Authors:  Matthew J Schipper; Kenneth F Koral; Anca M Avram; Mark S Kaminski; Yuni K Dewaraja
Journal:  Cancer Biother Radiopharm       Date:  2012-09       Impact factor: 3.099

4.  Quantitative (177)Lu SPECT (QSPECT) imaging using a commercially available SPECT/CT system.

Authors:  Jean-Mathieu Beauregard; Michael S Hofman; Jucilene M Pereira; Peter Eu; Rodney J Hicks
Journal:  Cancer Imaging       Date:  2011-06-15       Impact factor: 3.909

5.  Deadtime effects in quantification of 177Lu activity for radionuclide therapy.

Authors:  Carlos F Uribe; Pedro L Esquinas; Marjorie Gonzalez; Wei Zhao; Jesse Tanguay; Anna Celler
Journal:  EJNMMI Phys       Date:  2018-01-11
  5 in total

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