| Literature DB >> 11994744 |
Billy Tsai1, Yihong Ye, Tom A Rapoport.
Abstract
Proteins that are misfolded in the endoplasmic reticulum are transported back into the cytosol for destruction by the proteasome. This retro-translocation pathway has been co-opted by certain viruses, and by plant and bacterial toxins. The mechanism of retro-translocation is still mysterious, but several aspects of this process are now being unravelled.Mesh:
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Year: 2002 PMID: 11994744 DOI: 10.1038/nrm780
Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN: 1471-0072 Impact factor: 94.444