Literature DB >> 11994743

v-Src's hold over actin and cell adhesions.

Margaret C Frame1, Valerie J Fincham, Neil O Carragher, John A Wyke.   

Abstract

The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.

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Year:  2002        PMID： 11994743     DOI： 10.1038/nrm779

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  114 in total

1.  Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected].

Authors:  Yingchun Wang; Jonathan A Kelber; Hop S Tran Cao; Greg T Cantin; Rui Lin; Wei Wang; Sharmeela Kaushal; Jeanne M Bristow; Thomas S Edgington; Robert M Hoffman; Michael Bouvet; John R Yates; Richard L Klemke
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-01       Impact factor: 11.205

2.  MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts.

Authors:  Bruce D Cuevas; Amy N Abell; James A Witowsky; Toshiaki Yujiri; Nancy Lassignal Johnson; Kamala Kesavan; Marti Ware; Peter L Jones; Scott A Weed; Roberta L DeBiasi; Yoshitomo Oka; Kenneth L Tyler; Gary L Johnson
Journal:  EMBO J       Date:  2003-07-01       Impact factor: 11.598

3.  Src family kinases are involved in EphA receptor-mediated retinal axon guidance.

Authors:  Bernd Knöll; Uwe Drescher
Journal:  J Neurosci       Date:  2004-07-14       Impact factor: 6.167

Review 4.  Cell competition and its implications for development and cancer.

Authors:  Yoichiro Tamori; Wu-Min Deng
Journal:  J Genet Genomics       Date:  2011-09-21       Impact factor: 4.275

5.  Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling.

Authors:  Danislav S Spassov; Ching Hang Wong; Natalia Sergina; Deepika Ahuja; Michael Fried; Dean Sheppard; Mark M Moasser
Journal:  Mol Cell Biol       Date:  2010-12-28       Impact factor: 4.272

6.  Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growth.

Authors:  Elisa Giannoni; Francesca Buricchi; Giovanni Raugei; Giampietro Ramponi; Paola Chiarugi
Journal:  Mol Cell Biol       Date:  2005-08       Impact factor: 4.272

7.  Critical role of cortactin in actin ring formation and osteoclastic bone resorption.

Authors:  Takuma Matsubara; Akira Myoui; Fumiyo Ikeda; Kenji Hata; Hideki Yoshikawa; Riko Nishimura; Toshiyuki Yoneda
Journal:  J Bone Miner Metab       Date:  2006       Impact factor: 2.626

Review 8.  Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover.

Authors:  Neil O Carragher
Journal:  Clin Exp Metastasis       Date:  2008-10-29       Impact factor: 5.150

Review 9.  Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis.

Authors:  M P Kim; S I Park; S Kopetz; G E Gallick
Journal:  Cell Tissue Res       Date:  2008-09-25       Impact factor: 5.249

10.  JNK-mediated phosphorylation of paxillin in adhesion assembly and tension-induced cell death by the adenovirus death factor E4orf4.

Authors:  Nicolas Smadja-Lamère; Marie-Chloé Boulanger; Claudia Champagne; Philip E Branton; Josée N Lavoie
Journal:  J Biol Chem       Date:  2008-09-25       Impact factor: 5.157
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