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Literature DB >> 119946

Extracellular free calcium and fluid secretion by the rabbit lacrimal gland in vivo.

Abstract

A possible role of extracellular free Ca2+ in methacholine-induced fluid secretion in the in vivo rabbit lacrimal gland has been investigated. Lowering the extracellular Ca2+ concentration by either intra-arterial injection or infusion of EGTA at doses which caused no systemic effects produced a dose related and reversible inhibition of methacholine-induced secretion. The inhibitory effect of EGTA was diminished when EGTA chelated with CaCl2 in varying concentration ratios was administered. On the other hand, intra-arterial injection of CaCl2 potentiated fluid secretion stimulated by submaximal doses of methacholine. These results suggest that fluid secretion from the rabbit lacrimal gland is dependent on the extracellular free Ca2+ concentration.

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Year: 1979 PMID： 119946 DOI： 10.1007/bf00583713

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

11 in total

Review 1. Electrophysiology of mammalian gland cells.

Authors: O H Petersen
Journal: Physiol Rev Date: 1976-07 Impact factor: 37.312

2. TEARS AND THE LACRIMAL GLAND.

Authors: S Y BOTELHO
Journal: Sci Am Date: 1964-10 Impact factor: 2.142

3. The influence of calcium on the secretory response of the submaxillary gland to acetylcholine or to noradrenaline.

Authors: W W Douglas; A M Poisner
Journal: J Physiol Date: 1963-03 Impact factor: 5.182

4. Control by calcium of protein discharge and membrane permeability to potassium in the rat lacrimal gland.

Authors: J W Putney; R J Parod; S H Marier
Journal: Life Sci Date: 1977-06-01 Impact factor: 5.037

Review 5. The role of calcium in the release of neurotransmitter substances and hormones.

Authors: R P Rubin
Journal: Pharmacol Rev Date: 1970-09 Impact factor: 25.468

Review 6. Stimulus-secretion coupling: the concept and clues from chromaffin and other cells.

Authors: W W Douglas
Journal: Br J Pharmacol Date: 1968-11 Impact factor: 8.739

7. Intracellular Ca2+ injection causes membrane hyperpolarization and conductance increase in lacrimal acinar cells.

Authors: N Iwatsuki; O H Petersen
Journal: Pflugers Arch Date: 1978-11-14 Impact factor: 3.657

8. Secretory potentials, secretory rate and water permeability of the duct system in the cat submandibular gland during perfusion with calcium-free Locke's solution.

Authors: O H Petersen; J H Poulsen; N A Thorn
Journal: Acta Physiol Scand Date: 1967 Oct-Nov

9. A calcium ionophore-induced secretion in rabbit lacrimal gland in vivo.

Authors: C Pholpramool; V Tangkrisanavinont
Journal: Life Sci Date: 1976-08-01 Impact factor: 5.037

10. Membrane potential, resistance, and intercellular communication in the lacrimal gland: effects of acetylcholine and adrenaline.

Authors: N Iwatsuki; O H Petersen
Journal: J Physiol Date: 1978-02 Impact factor: 5.182

6 in total

1. Nervous control of membrane conductance in mouse lacrimal acinar cells.

Authors: G T Pearson; O H Petersen
Journal: Pflugers Arch Date: 1984-01 Impact factor: 3.657

2. Ultracytochemical localization of Ca++-ATPase activity in the paraphyseal epithelial cells of the frog, Rana esculenta.

Authors: S Ueno; H Umar; H J Bambauer; M Ueck
Journal: Cell Tissue Res Date: 1984 Impact factor: 5.249