Literature DB >> 11992790

Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors.

Chi Choi1, Jia-He Li, Mark Vaal, Christine Thomas, David Limburg, Yong-Qian Wu, Yi Chen, Raj Soni, Chad Scott, Douglas T Ross, Hong Guo, Pamela Howorth, Heather Valentine, Shi Liang, Dawn Spicer, Mike Fuller, Joseph Steiner, Gregory S Hamilton.   

Abstract

Using simple, inexpensive equipment, we have used solution-phase parallel synthesis to rapidly prepare hundreds of sulfonamide- and urea-containing FKBP inhibitors, resulting in rapid identification of extremely potent compounds in these series.

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Year:  2002        PMID: 11992790     DOI: 10.1016/s0960-894x(02)00147-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

Review 1.  Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: Focus on microtubule targeting.

Authors:  Isabella Barbiero; Massimiliano Bianchi; Charlotte Kilstrup-Nielsen
Journal:  J Neuroendocrinol       Date:  2021-09-08       Impact factor: 3.870

  1 in total

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