Literature DB >> 11992785

Heterocyclic nucleoside analogues: design and synthesis of antiviral, modified nucleosides containing isoxazole heterocycles.

Yoon-Suk Lee1, Byeang Hyean Kim.   

Abstract

We have designed and synthesized novel antiviral nucleoside analogues, which consist of isoxazole rings as modified sugars and nucleobases (thymine, uracil, and 5-fluorouracil) with a methylene linker between them. These compounds represent a new class of modified nucleoside analogues and some of them show potent antiviral activities against Polio virus (Coxsackie B type 3 and Vesicular Stomatitis).

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Year:  2002        PMID： 11992785     DOI： 10.1016/s0960-894x(02)00182-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  Synthesis of cyclopentanyl carbocyclic 5-fluorocytosine ((-)-5-fluorocarbodine) using a facially selective hydrogenation approach.

Authors:  Jong Hyun Cho; Franck Amblard; Steven J Coats; Raymond F Schinazi
Journal:  J Org Chem       Date:  2012-12-26       Impact factor: 4.354

2.  Diversity oriented synthesis and IKK inhibition of aminobenzimidazole tethered quinazoline-2,4-diones, thioxoquinazolin-4-ones, benzodiazepine-2,3,5-triones, isoxazoles and isoxazolines.

Authors:  Sureshbabu Dadiboyena; Aïcha Arfaoui; Hassen Amri; F Javier Piedrafita; Adel Nefzi
Journal:  Bioorg Med Chem Lett       Date:  2014-12-08       Impact factor: 2.823

3.  Solid Phase Synthesis of Isoxazole and Isoxazoline-carboxamides via [2+3]-Dipolar Cycloaddition Using Resin-bound Alkynes or Alkenes.

Authors:  Sureshbabu Dadiboyena; Adel Nefzi
Journal:  Tetrahedron Lett       Date:  2012-04-18       Impact factor: 2.415

4.  5-Methyl-3-[1-(2-pyridylmeth-yl)-1H-benzimidazol-2-ylmeth-yl]isoxazole.

Authors:  Mohamadou Lamine Doumbia; Rachid Bouhfid; El Mokhtar Essassi; Lahcen El Ammari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-10-10

5.  Isoxazoles from 1,1-Disubstituted Bromoalkenes.

Authors:  Sureshbabu Dadiboyena; Jianping Xu; Ashton T Hamme
Journal:  Tetrahedron Lett       Date:  2007-02-12       Impact factor: 2.415

6.  Isoxazole derivatives as new nitric oxide elicitors in plants.

Authors:  Anca Oancea; Emilian Georgescu; Florentina Georgescu; Alina Nicolescu; Elena Iulia Oprita; Catalina Tudora; Lucian Vladulescu; Marius-Constantin Vladulescu; Florin Oancea; Calin Deleanu
Journal:  Beilstein J Org Chem       Date:  2017-04-06       Impact factor: 2.883

7.  Design, synthesis, antiviral and cytostatic activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates as acyclic nucleotide analogues.

Authors:  Iwona E Głowacka; Jan Balzarini; Graciela Andrei; Robert Snoeck; Dominique Schols; Dorota G Piotrowska
Journal:  Bioorg Med Chem       Date:  2014-05-20       Impact factor: 3.641

8.  Synthesis, structure-activity relationship and antiviral activity of 3'-N,N-dimethylamino-2',3'-dideoxythymidine and its prodrugs.

Authors:  Ramendra K Singh; Dipti Yadav; Diwakar Rai; Garima Kumari; C Pannecouque; Erik De Clercq
Journal:  Eur J Med Chem       Date:  2010-05-20       Impact factor: 6.514

9.  Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.

Authors:  Yoon-Suk Lee; Sun Min Park; Byeang Hyean Kim
Journal:  Bioorg Med Chem Lett       Date:  2008-12-31       Impact factor: 2.823

10.  The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker.

Authors:  Iwona E Głowacka; Jan Balzarini; Andrzej E Wróblewski
Journal:  Eur J Med Chem       Date:  2013-10-30       Impact factor: 6.514
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