Literature DB >> 11992780

Shikonin derivatives: synthesis and inhibition of human telomerase.

Qun Lu1, Weijun Liu, Jian Ding, Junchao Cai, Wenhu Duan.   

Abstract

We synthesized DL-shikonin, shikonin, alkanin, and their cyclo-derivatives and acyl-derivatives. These compounds have low cytotoxicity, as well as inhibitory activity against the telomerase enzyme, except cyclo-derivatives.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11992780     DOI： 10.1016/s0960-894x(02)00158-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Synthesis and cytotoxic activities of some 2-arylnaphtho[2,3-d]oxazole-4,9-dione derivatives on androgen-dependent (LNCaP) and androgen-independent (PC3) human prostate cancer cell lines.

Authors:  Yakini Brandy; Innocent Ononiwu; Dolapo Adedeji; Vonetta Williams; Claudia Mouamba; Yasmine Kanaan; Robert L Copeland; Dwayne A Wright; Ray J Butcher; Samuel R Denmeade; Oladapo Bakare
Journal:  Invest New Drugs       Date:  2011-01-18       Impact factor: 3.850

Review 2.  Development of Certain Protein Kinase Inhibitors with the Components from Traditional Chinese Medicine.

Authors:  Minghua Liu; Ge Zhao; Shousong Cao; Yangyang Zhang; Xiaofang Li; Xiukun Lin
Journal:  Front Pharmacol       Date:  2017-01-09       Impact factor: 5.810

Review 3.  Telomerase Inhibitors from Natural Products and Their Anticancer Potential.

Authors:  Kumar Ganesan; Baojun Xu
Journal:  Int J Mol Sci       Date:  2017-12-21       Impact factor: 5.923

4.  Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives.

Authors:  Yakini Brandy; Nailah Brandy; Emmanuel Akinboye; Malik Lewis; Claudia Mouamba; Seshat Mack; Ray J Butcher; Alan J Anderson; Oladapo Bakare
Journal:  Molecules       Date:  2013-02-04       Impact factor: 4.411

5.  Alkannin, HSP70 inducer, protects against UVB-induced apoptosis in human keratinocytes.

Authors:  Yoko Yoshihisa; Mariame Ali Hassan; Yukihiro Furusawa; Yoshiaki Tabuchi; Takashi Kondo; Tadamichi Shimizu
Journal:  PLoS One       Date:  2012-10-22       Impact factor: 3.240

6.  Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells.

Authors:  Seyed Abbas Mirzaei; Somayeh Reiisi; Parmida Ghiasi Tabari; Abolfazl Shekari; Fatemeh Aliakbari; Elaheh Azadfallah; Fatemeh Elahian
Journal:  Sci Rep       Date:  2018-02-22       Impact factor: 4.379

7.  Antimicrobial and cytotoxic isohexenylnaphthazarins from Arnebia euchroma (Royle) Jonst. (Boraginaceae) callus and cell suspension culture.

Authors:  Harilaos Damianakos; Nadine Kretschmer; Katarzyna Sykłowska-Baranek; Agnieszka Pietrosiuk; Rudolf Bauer; Ioanna Chinou
Journal:  Molecules       Date:  2012-12-03       Impact factor: 4.411

8.  Synthesis and Pharmacological In Vitro Investigations of Novel Shikonin Derivatives with a Special Focus on Cyclopropane Bearing Derivatives.

Authors:  Nadine Kretschmer; Antje Hufner; Christin Durchschein; Katrin Popodi; Beate Rinner; Birgit Lohberger; Rudolf Bauer
Journal:  Int J Mol Sci       Date:  2021-03-09       Impact factor: 5.923

Review 9.  Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review.

Authors:  Zhiqin Zhang; Jie Bai; Yawen Zeng; Mengru Cai; Yu Yao; Huimin Wu; Longtai You; Xiaoxv Dong; Jian Ni
Journal:  Pharm Biol       Date:  2020-12       Impact factor: 3.889
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.