Literature DB >> 11992774

Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group.

Shinichi Uesato1, Manabu Kitagawa, Yasuo Nagaoka, Taishi Maeda, Hiroshi Kuwajima, Takao Yamori.   

Abstract

Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with the 1,4-phenylene group yielded the promising HDAC inhibitors which possess a terminal bicyclic aryl amide.

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Year:  2002        PMID： 11992774     DOI： 10.1016/s0960-894x(02)00175-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  The synthesis and evaluation of N1-(4-(2-[18F]-fluoroethyl)phenyl)-N8-hydroxyoctanediamide ([18F]-FESAHA), a PET radiotracer designed for the delineation of histone deacetylase expression in cancer.

Authors:  Brian M Zeglis; NagaVaraKishore Pillarsetty; Vadim Divilov; Ronald A Blasberg; Jason S Lewis
Journal:  Nucl Med Biol       Date:  2011-03-03       Impact factor: 2.408

2.  Homology modeling, force field design, and free energy simulation studies to optimize the activities of histone deacetylase inhibitors.

Authors:  Hwangseo Park; Sangyoub Lee
Journal:  J Comput Aided Mol Des       Date:  2004-06       Impact factor: 3.686

3.  Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid.

Authors:  Anton V Bieliauskas; Sujith V W Weerasinghe; Mary Kay H Pflum
Journal:  Bioorg Med Chem Lett       Date:  2007-02-08       Impact factor: 2.823

4.  Synthesis of sulfonamides and evaluation of their histone deacetylase (HDAC) activity.

Authors:  Seikwan Oh; Hyung-In Moon; Il-Hong Son; Jae-Chul Jung; Mitchell A Avery
Journal:  Molecules       Date:  2007-05-24       Impact factor: 4.411

5.  Search for the pharmacophore of histone deacetylase inhibitors using pharmacophore query and docking study.

Authors:  Atefeh Haji Agha Bozorgi; Afshin Zarghi
Journal:  Iran J Pharm Res       Date:  2014       Impact factor: 1.696

6.  First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.

Authors:  Daniel Herp; Johannes Ridinger; Dina Robaa; Stephen A Shinsky; Karin Schmidtkunz; Talha Z Yesiloglu; Theresa Bayer; Raphael R Steimbach; Corey J Herbst-Gervasoni; Annika Merz; Christophe Romier; Peter Sehr; Nikolas Gunkel; Aubry K Miller; David W Christianson; Ina Oehme; Wolfgang Sippl; Manfred Jung
Journal:  Chembiochem       Date:  2022-06-10       Impact factor: 3.461
  6 in total

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