| Literature DB >> 11992678 |
El-Refaie Kenawy1, Gary L Bowlin, Kevin Mansfield, John Layman, David G Simpson, Elliot H Sanders, Gary E Wnek.
Abstract
Electrospun fiber mats are explored as drug delivery vehicles using tetracycline hydrochloride as a model drug. The mats were made either from poly(lactic acid) (PLA), poly(ethylene-co-vinyl acetate) (PEVA), or from a 50:50 blend of the two. The fibers were electrospun from chloroform solutions containing a small amount of methanol to solubilize the drug. The release of the tetracycline hydrochloride from these new drug delivery systems was followed by UV-VIS spectroscopy. Release profiles from the electrospun mats were compared to a commercially available drug delivery system, Actisite (Alza Corporation, Palo Alto, CA), as well as to cast films of the various formulations.Entities:
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Year: 2002 PMID： 11992678 DOI： 10.1016/s0168-3659(02)00041-x
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776