| Literature DB >> 11991682 |
P K Kim1, R Mahidhara, D W Seol.
Abstract
Toxicity of chemotherapeutic agents against cancer cells is mediated through the initiation of programmed cell death. Apoptosis is an evolutionarily conserved cascade of intracellular proteolytic events propagated by a family of cysteine proteases called caspases. Many receptor- and non-receptor-mediated death signals induce apoptosis via activation of caspase-8 (FLICE/MACH). Mechanisms of tumor resistance to cytotoxic drugs through decreased apoptosis may occur by altered expression of caspase-8, upregulation of caspase-8 inhibitors like FLIP (FLICE-like Inhibitory Protein), or sequestration of caspase-8 by Bcl-2. Modulation of caspase-8 and apoptosis may be a therapeutic strategy for sensitization of drug-resistant malignancies to radiation or combination chemotherapy. Copyright 2002, Elsevier Science Ltd. All rights reserved.Entities:
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Year: 2001 PMID： 11991682 DOI： 10.1054/drup.2001.0223
Source DB: PubMed Journal: Drug Resist Updat ISSN： 1368-7646 Impact factor: 18.500