Literature DB >> 11991544

Regulation of pyruvate dehydrogenase (PDH) activity in human skeletal muscle during exercise.

Lawrence L Spriet1, George J F Heigenhauser.   

Abstract

Pyruvate dehydrogenase is a mitochondrial multienzyme complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A and regulates the entry of carbohydrate into the tricarboxylic acid cycle for oxidation. During exercise, pyruvate dehydrogenase activation in human skeletal muscle is proportional to the relative aerobic power output (percent VO2max) and is regulated by increases in Ca2+, free ADP, and pyruvate concentrations.

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Year:  2002        PMID： 11991544     DOI： 10.1097/00003677-200204000-00009

Source DB:  PubMed          Journal:  Exerc Sport Sci Rev        ISSN： 0091-6331            Impact factor:   6.230


  28 in total

1.  Pulmonary O2 uptake and leg blood flow kinetics during moderate exercise are slowed by hyperventilation-induced hypocapnic alkalosis.

Authors:  Lisa M K Chin; George J F Heigenhauser; Donald H Paterson; John M Kowalchuk
Journal:  J Appl Physiol (1985)       Date:  2010-03-25

2.  Regulation and function of Ca2+-calmodulin-dependent protein kinase II of fast-twitch rat skeletal muscle.

Authors:  Adam J Rose; Thomas J Alsted; J Bjarke Kobberø; Erik A Richter
Journal:  J Physiol       Date:  2007-02-01       Impact factor: 5.182

3.  Research in exercise physiology and dyspnea at McMaster University.

Authors:  Norman L Jones
Journal:  Can Respir J       Date:  2007-10       Impact factor: 2.409

4.  Regulation of substrate use during the marathon.

Authors:  Lawrence L Spriet
Journal:  Sports Med       Date:  2007       Impact factor: 11.136

5.  AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle.

Authors:  Angela C Smith; Clinton R Bruce; David J Dyck
Journal:  J Physiol       Date:  2005-03-17       Impact factor: 5.182

Review 6.  Trimetazidine and Other Metabolic Modifiers.

Authors:  Giacinta Guarini; Alda Huqi; Doralisa Morrone; Paola Francesca Giuseppina Capozza; Mario Marzilli
Journal:  Eur Cardiol       Date:  2018-12

7.  Effect of high-fat and high-carbohydrate diets on pulmonary O2 uptake kinetics during the transition to moderate-intensity exercise.

Authors:  J A Raper; L K Love; D H Paterson; S J Peters; G J F Heigenhauser; J M Kowalchuk
Journal:  J Appl Physiol (1985)       Date:  2014-10-02

8.  Low levels of lipopolysaccharide modulate mitochondrial oxygen consumption in skeletal muscle.

Authors:  Madlyn I Frisard; Yaru Wu; Ryan P McMillan; Kevin A Voelker; Kristin A Wahlberg; Angela S Anderson; Nabil Boutagy; Kyle Resendes; Eric Ravussin; Matthew W Hulver
Journal:  Metabolism       Date:  2014-11-28       Impact factor: 8.694

9.  Effect of hyperventilation and prior heavy exercise on O2 uptake and muscle deoxygenation kinetics during transitions to moderate exercise.

Authors:  Lisa M K Chin; George J F Heigenhauser; Donald H Paterson; John M Kowalchuk
Journal:  Eur J Appl Physiol       Date:  2009-11-28       Impact factor: 3.078

10.  Enhancement of muscle mitochondrial function by growth hormone.

Authors:  Kevin R Short; Niels Moller; Maureen L Bigelow; Jill Coenen-Schimke; K Sreekumaran Nair
Journal:  J Clin Endocrinol Metab       Date:  2007-11-13       Impact factor: 5.958
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