Literature DB >> 11990076

Repeated treatment with SA4503, a selective sigma1 receptor agonist, up-regulates alpha-adrenergic system. a behavioral study.

G Skuza1, W Kolasiewicz.   

Abstract

The obtained results indicate that SA4503, a selective sigma1 receptor agonist, given repeatedly (but not acutely) enhanced the effects of phenylephrine, alpha1-adrenoceptor agonist, and clonidine (stimulating the postsynaptic alpha1-adrenoceptors at high dose) in behavioral models (hyperexploratory activity in rats and aggressiveness in mice, respectively).

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Year:  2001        PMID： 11990076

Source DB:  PubMed          Journal:  Pol J Pharmacol        ISSN： 1230-6002


  3 in total

1.  Sigma-1 receptor mediates acquisition of alcohol drinking and seeking behavior in alcohol-preferring rats.

Authors:  Angelo Blasio; Marta Valenza; Malliga R Iyer; Kenner C Rice; Luca Steardo; T Hayashi; Pietro Cottone; Valentina Sabino
Journal:  Behav Brain Res       Date:  2015-04-04       Impact factor: 3.332

2.  Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats.

Authors:  Valentina Sabino; Pietro Cottone; Angelo Blasio; Malliga R Iyer; Luca Steardo; Kenner C Rice; Bruno Conti; George F Koob; Eric P Zorrilla
Journal:  Neuropsychopharmacology       Date:  2011-02-23       Impact factor: 7.853

3.  Ethanol-related behaviors in mice lacking the sigma-1 receptor.

Authors:  Marta Valenza; Alyssa DiLeo; Luca Steardo; Pietro Cottone; Valentina Sabino
Journal:  Behav Brain Res       Date:  2015-10-14       Impact factor: 3.332
  3 in total

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