Literature DB >> 11988867

Inhibition of vascular endothelial growth factor expression and production by triptolide.

Ke-Bin Hu, Zhi-Hong Liu, Dong Liu, Lei-Shi Li.   

Abstract

Triptolide, the major component of the diterpenoids of the Chinese herb Tripterygium wilfordii Hook f. (Celastraceae), inhibited vascular endothelial growth factor expression and secretion in endothelial cells treated by 12-O-tetradecanoylphorbol 13-acetate dose-dependently. This effect may be one of the mechanisms underlying the therapeutic effects of triptolide on rheumatoid arthritis.

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Year:  2002        PMID: 11988867     DOI: 10.1055/s-2002-26737

Source DB:  PubMed          Journal:  Planta Med        ISSN: 0032-0943            Impact factor:   3.352


  3 in total

1.  Vitexicarpin acts as a novel angiogenesis inhibitor and its target network.

Authors:  Bo Zhang; Lu Liu; Shiwen Zhao; Xu Wang; Liyang Liu; Shao Li
Journal:  Evid Based Complement Alternat Med       Date:  2013-02-12       Impact factor: 2.629

2.  Disseminated cutaneous Kaposi sarcoma in a patient receiving triptolide/tripdiolide for rheumatoid arthritis.

Authors:  Alicja E Grzegorzewska; Dorota Frankiewicz; Danuta Bręborowicz; Irena Matławska; Wiesława Bylka
Journal:  Med Sci Monit       Date:  2012-08

3.  Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts.

Authors:  Natsuko Kusunoki; Ryuta Yamazaki; Hidero Kitasato; Moroe Beppu; Haruhito Aoki; Shinichi Kawai
Journal:  BMC Pharmacol       Date:  2004-02-17
  3 in total

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