Literature DB >> 11988767

The subcellular destinations of APC proteins.

Mariann Bienz1.   

Abstract

Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon, and is conserved in various organisms. Its best understood function is the destabilization of beta-catenin, a key effector of the Wnt signalling pathway. APC proteins are highly motile, and shuttle between several subcellular destinations. These destinations have prompted the discovery of new functions for the APC proteins, and this multitasking of APC might explain why its loss often leads to cancer.

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Year:  2002        PMID： 11988767     DOI： 10.1038/nrm806

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  68 in total

Review 1.  Stem cell in gastrointestinal structure and neoplastic development.

Authors:  M Brittan; N A Wright
Journal:  Gut       Date:  2004-06       Impact factor: 23.059

2.  Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism.

Authors:  Michaella Velichkova; Tama Hasson
Journal:  Mol Cell Biol       Date:  2005-06       Impact factor: 4.272

3.  Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.

Authors:  V M Draviam; I Shapiro; B Aldridge; P K Sorger
Journal:  EMBO J       Date:  2006-06-08       Impact factor: 11.598

4.  Distribution of E-cadherin and beta-catenin in relation to cell maturation and cell extrusion in rat and mouse small intestines.

Authors:  Lars-Inge Larsson
Journal:  Histochem Cell Biol       Date:  2006-05-30       Impact factor: 4.304

Review 5.  Asymmetric stem cell division and function of the niche in the Drosophila male germ line.

Authors:  Yukiko M Yamashita; Margaret T Fuller
Journal:  Int J Hematol       Date:  2005-12       Impact factor: 2.490

Review 6.  Adult Mesenchymal Stem Cells and Radiation Injury.

Authors:  Juliann G Kiang
Journal:  Health Phys       Date:  2016-08       Impact factor: 1.316

7.  Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export.

Authors:  Sten Strunze; Lloyd C Trotman; Karin Boucke; Urs F Greber
Journal:  Mol Biol Cell       Date:  2005-04-06       Impact factor: 4.138

8.  NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers.

Authors:  Wen Zhou; Ye Yang; Jiliang Xia; He Wang; Mohamed E Salama; Wei Xiong; Hongwei Xu; Shashirekha Shetty; Tiehua Chen; Zhaoyang Zeng; Lei Shi; Maurizio Zangari; Rodney Miles; David Bearss; Guido Tricot; Fenghuang Zhan
Journal:  Cancer Cell       Date:  2013-01-14       Impact factor: 31.743

Review 9.  The way Wnt works: components and mechanism.

Authors:  Kenyi Saito-Diaz; Tony W Chen; Xiaoxi Wang; Curtis A Thorne; Heather A Wallace; Andrea Page-McCaw; Ethan Lee
Journal:  Growth Factors       Date:  2012-12-21       Impact factor: 2.511

10.  The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex.

Authors:  Yukako Yokota; Woo-Yang Kim; Youjun Chen; Xinshuo Wang; Amelia Stanco; Yutaro Komuro; William Snider; E S Anton
Journal:  Neuron       Date:  2009-01-15       Impact factor: 17.173
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