Literature DB >> 11988219

Specific interactions of the antimicrobial peptide cyclic beta-sheet tachyplesin I with lipopolysaccharides.

Yutaka Hirakura1, Satoe Kobayashi, Katsumi Matsuzaki.   

Abstract

The cyclic beta-sheet antimicrobial peptide tachyplesin I (T-SS) was found to show 280-fold higher affinity for lipopolysaccharides (LPS) compared with acidic phospholipids, whereas the linear alpha-helical peptide F5W-magainin 2 (MG2) could not discriminate between LPS and acidic phospholipids. The recognition site was the lipid A moiety and the cyclic structure was crucial to this specific binding. The cyclic structure also endowed the peptide with very rapid outer membrane (OM) permeabilization.

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Year:  2002        PMID: 11988219     DOI: 10.1016/s0005-2736(02)00358-9

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  13 in total

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4.  Cyclic antimicrobial R-, W-rich peptides: the role of peptide structure and E. coli outer and inner membranes in activity and the mode of action.

Authors:  Christof Junkes; Richard D Harvey; Kenneth D Bruce; Rudolf Dölling; Mojtaba Bagheri; Margitta Dathe
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6.  Interaction of W-substituted analogs of cyclo-RRRWFW with bacterial lipopolysaccharides: the role of the aromatic cluster in antimicrobial activity.

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Review 8.  Control of Biofilm Formation: Antibiotics and Beyond.

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9.  Deletion of all cysteines in tachyplesin I abolishes hemolytic activity and retains antimicrobial activity and lipopolysaccharide selective binding.

Authors:  Ayyalusamy Ramamoorthy; Sathiah Thennarasu; Anmin Tan; Kiran Gottipati; Sreeja Sreekumar; Deborah L Heyl; Florence Y P An; Charles E Shelburne
Journal:  Biochemistry       Date:  2006-05-23       Impact factor: 3.162

10.  Efficacy of the combination of tachyplesin III and clarithromycin in rat models of Escherichia coli sepsis.

Authors:  Oscar Cirioni; Roberto Ghiselli; Carmela Silvestri; Wojciech Kamysz; Fiorenza Orlando; Alessandra Riva; Elzbieta Kamysz; Sefora Castelletti; Marco Rocchi; Vittorio Saba; Giorgio Scalise; Andrea Giacometti
Journal:  Antimicrob Agents Chemother       Date:  2008-09-08       Impact factor: 5.191

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