| Literature DB >> 11988219 |
Yutaka Hirakura1, Satoe Kobayashi, Katsumi Matsuzaki.
Abstract
The cyclic beta-sheet antimicrobial peptide tachyplesin I (T-SS) was found to show 280-fold higher affinity for lipopolysaccharides (LPS) compared with acidic phospholipids, whereas the linear alpha-helical peptide F5W-magainin 2 (MG2) could not discriminate between LPS and acidic phospholipids. The recognition site was the lipid A moiety and the cyclic structure was crucial to this specific binding. The cyclic structure also endowed the peptide with very rapid outer membrane (OM) permeabilization.Entities:
Mesh:
Substances:
Year: 2002 PMID: 11988219 DOI: 10.1016/s0005-2736(02)00358-9
Source DB: PubMed Journal: Biochim Biophys Acta ISSN: 0006-3002