Literature DB >> 11988081

L-Lactate transport into rat heart mitochondria and reconstruction of the L-lactate/pyruvate shuttle.

Daniela Valenti1, Lidia de Bari, Anna Atlante, Salvatore Passarella.   

Abstract

In vitro reconstruction of the L-lactate/pyruvate shuttle has been performed, which allows NADH oxidation outside rat heart mitochondria. Such a shuttle occurs due to the combined action of the novel mitochondrial L-lactate/pyruvate antiporter, which differs from the monocarboxylate carrier, and the mitochondrial L-lactate dehydrogenase. The rate of L-lactate/pyruvate antiport proved to regulate the shuttle in vitro.

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Year:  2002        PMID： 11988081      PMCID： PMC1222550          DOI： 10.1042/bj3640101

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

Review 1.  Intra- and extra-cellular lactate shuttles.

Authors:  G A Brooks
Journal:  Med Sci Sports Exerc       Date:  2000-04       Impact factor: 5.411

2.  The role of metal ions in the transport of substrates in mitochondria.

Authors:  S Passarella; F Palmieri; E Quagliariello
Journal:  FEBS Lett       Date:  1973-12-15       Impact factor: 4.124

3.  Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1.

Authors:  G A Brooks; M A Brown; C E Butz; J P Sicurello; H Dubouchaud
Journal:  J Appl Physiol (1985)       Date:  1999-11

4.  Upregulation of the cardiac monocarboxylate transporter MCT1 in a rat model of congestive heart failure.

Authors:  E Jóhannsson; P K Lunde; C Heddle; I Sjaastad; M J Thomas; L Bergersen; A P Halestrap; T W Blackstad; O P Ottersen; O M Sejersted
Journal:  Circulation       Date:  2001-08-07       Impact factor: 29.690

5.  AZT inhibition of the ADP/ATP antiport in isolated rat heart mitochondria.

Authors:  D Valenti; M Barile; S Passarella
Journal:  Int J Mol Med       Date:  2000-07       Impact factor: 4.101

6.  Metabolic adaptation of the hypertrophied heart: role of the malate/aspartate and alpha-glycerophosphate shuttles.

Authors:  B E Rupert; J L Segar; B C Schutte; T D Scholz
Journal:  J Mol Cell Cardiol       Date:  2000-12       Impact factor: 5.000

7.  The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors.

Authors:  A P Halestrap
Journal:  Biochem J       Date:  1975-04       Impact factor: 3.857

8.  Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle.

Authors:  H Dubouchaud; G E Butterfield; E E Wolfel; B C Bergman; G A Brooks
Journal:  Am J Physiol Endocrinol Metab       Date:  2000-04       Impact factor: 4.310

9.  Kinetic studies of the uptake of aspartate aminotransferase and malate dehydrogenase into mitochondria in vitro.

Authors:  E Marra; S Passarella; E Casamassima; E Perlino; S Doonan; E Quagliariello
Journal:  Biochem J       Date:  1985-06-01       Impact factor: 3.857

10.  Oxaloacetate permeation in rat kidney mitochondria: pyruvate/oxaloacetate and malate/oxaloacetate translocators.

Authors:  S Passarella; A Atlante; E Quagliariello
Journal:  Biochem Biophys Res Commun       Date:  1985-05-31       Impact factor: 3.575
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  15 in total

Review 1.  Lactate metabolism: historical context, prior misinterpretations, and current understanding.

Authors:  Brian S Ferguson; Matthew J Rogatzki; Matthew L Goodwin; Daniel A Kane; Zachary Rightmire; L Bruce Gladden
Journal:  Eur J Appl Physiol       Date:  2018-01-10       Impact factor: 3.078

2.  D-Lactate transport and metabolism in rat liver mitochondria.

Authors:  Lidia de Bari; Anna Atlante; Nicoletta Guaragnella; Giovanni Principato; Salvatore Passarella
Journal:  Biochem J       Date:  2002-07-15       Impact factor: 3.857

Review 3.  Tracing the lactate shuttle to the mitochondrial reticulum.

Authors:  George A Brooks; Casey C Curl; Robert G Leija; Adam D Osmond; Justin J Duong; Jose A Arevalo
Journal:  Exp Mol Med       Date:  2022-09-08       Impact factor: 12.153

4.  Exercise-induced changes of MCT1 in cardiac and skeletal muscles of diabetic rats induced by high-fat diet and STZ.

Authors:  Rohollah Nikooie; Hamid Rajabi; Reza Gharakhanlu; Fereshteh Atabi; Kobra Omidfar; Malihe Aveseh; Bagher Larijani
Journal:  J Physiol Biochem       Date:  2013-05-29       Impact factor: 4.158

5.  Partial reconstruction of in vitro gluconeogenesis arising from mitochondrial l-lactate uptake/metabolism and oxaloacetate export via novel L-lactate translocators.

Authors:  Lidia De Bari; Anna Atlante; Daniela Valenti; Salvatore Passarella
Journal:  Biochem J       Date:  2004-05-15       Impact factor: 3.857

6.  Myocardial redox state during coronary artery bypass grafting assessed with microdialysis.

Authors:  Ludger Bahlmann; Martin Misfeld; Stephan Klaus; Alexander Leptien; Matthias Heringlake; Peter Schmucker; Hans-Hinrich Sievers; Urban Ungerstedt; Ernst-Guenther Kraatz
Journal:  Intensive Care Med       Date:  2004-02-24       Impact factor: 17.440

7.  Intracellular shuttle: the lactate aerobic metabolism.

Authors:  Rogério Santos de Oliveira Cruz; Rafael Alves de Aguiar; Tiago Turnes; Rafael Penteado Dos Santos; Mariana Fernandes Mendes de Oliveira; Fabrizio Caputo
Journal:  ScientificWorldJournal       Date:  2012-04-19

8.  Evidence for the mitochondrial lactate oxidation complex in rat neurons: demonstration of an essential component of brain lactate shuttles.

Authors:  Takeshi Hashimoto; Rajaa Hussien; Hyung-Sook Cho; Daniela Kaufer; George A Brooks
Journal:  PLoS One       Date:  2008-08-13       Impact factor: 3.240

9.  The mitochondrial L-lactate dehydrogenase affair.

Authors:  Salvatore Passarella; Gianluca Paventi; Roberto Pizzuto
Journal:  Front Neurosci       Date:  2014-12-09       Impact factor: 4.677

Review 10.  Mitochondrial lactate metabolism: history and implications for exercise and disease.

Authors:  Brian Glancy; Daniel A Kane; Andreas N Kavazis; Matthew L Goodwin; Wayne T Willis; L Bruce Gladden
Journal:  J Physiol       Date:  2020-05-27       Impact factor: 6.228
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