Literature DB >> 11985850

Antiplasmodial activity of naphthoquinones and one anthraquinone from Stereospermum kunthianum.

Bernardina Onegi1, Carola Kraft, Inga Köhler, Marion Freund, Kristina Jenett-Siems, Karsten Siems, Gabriele Beyer, Matthias F Melzig, Ulrich Bienzle, Eckart Eich.   

Abstract

A lipophilic extract of the root bark of Stereospermum kunthianum revealed antiplasmodial activity in vitro. Bioassay-guided fractionation led to the isolation of four novel naphthoquinones (sterekunthals A and B, pyranokunthones A and B) and one novel anthraquinone (anthrakunthone) together with the known naphthoquinone pinnatal. The structures of the novel compounds were determined by comprehensive analyses of their 1D and 2D NMR data. The antiplasmodial activities and toxicity against the endothelial cell line ECV-304 of the isolated compounds have been assessed.

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Year:  2002        PMID： 11985850     DOI： 10.1016/s0031-9422(02)00072-9

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  8 in total

1.  Aqueous stem bark extract of Stereospermum kunthianum (Cham, Sandrine Petit) protects against generalized seizures in pentylenetetrazole and electro-convulsive models in rodents.

Authors:  F P Ching; E K I Omogbai; I O Otokiti
Journal:  Afr J Tradit Complement Altern Med       Date:  2009-07-03

Review 2.  Medicinal plants traditionally used in Mali for dysmenorrhea.

Authors:  Rokia Sanogo
Journal:  Afr J Tradit Complement Altern Med       Date:  2011-07-03

3.  Antiinflammatory Activity of Aqueous Extract of Stereospermum kunthianum (Cham, Sandrine Petit) Stem Bark in Rats.

Authors:  F P Ching; E K I Omogbai; S O Okpo; R I Ozolua
Journal:  Indian J Pharm Sci       Date:  2009-01       Impact factor: 0.975

4.  Cycloolivil, a lignan from the roots of Stereospermum suaveolens.

Authors:  B Abdul Wahab Sab; Janani Jacob; Gururaja Giligar Manjunath; Vineet Kumar Singh; Deepak Mundkinajeedu; Shashidhara Shankarappa
Journal:  Pharmacognosy Res       Date:  2015 Jan-Mar

Review 5.  Bignoniaceae metabolites as semiochemicals.

Authors:  Lucía Castillo; Carmen Rossini
Journal:  Molecules       Date:  2010-10-14       Impact factor: 4.411

6.  Anthraquinones of the roots of Pentas micrantha.

Authors:  Milkyas Endale; Annabel Ekberg; John Patrick Alao; Hoseah M Akala; Albert Ndakala; Per Sunnerhagen; Máté Erdélyi; Abiy Yenesew
Journal:  Molecules       Date:  2012-12-27       Impact factor: 4.411

7.  Design, Synthesis, and Biological Evaluation of Novel Fused Spiro-4H-Pyran Derivatives as Bacterial Biofilm Disruptor.

Authors:  Mohammad Irfan; Parvez Khan; Mohammad Abid; Md Musawwer Khan
Journal:  ACS Omega       Date:  2019-09-30

8.  Ethnobotanical study of plants used by the traditional healers to treat malaria in Mogovolas district, northern Mozambique.

Authors:  Leonardo Manuel; Aurélio Bechel; Emília Virgínia Noormahomed; Delfina Fernandes Hlashwayo; Maria do Céu Madureira
Journal:  Heliyon       Date:  2020-12-18
  8 in total

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