Literature DB >> 11985342

Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression.

J M Wierońska1, P Brański, B Szewczyk, A Pałucha, M Papp, P Gruca, E Moryl, A Pilc.   

Abstract

The aim of our study was to investigate the level of metabotropic glutamate receptors (mGluRs) in the brains of rats after chronic mild stress. Using Western blotting procedure we showed that the level of mGluR5 receptor protein was increased in CA1 and decreased in CA3 region of the hippocampus. Our results indicate that mGluR5 can possibly be engaged in the mechanism of depression.

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Year:  2001        PMID： 11985342

Source DB:  PubMed          Journal:  Pol J Pharmacol        ISSN： 1230-6002


  19 in total

Review 1.  Neurobiology of chronic mild stress: parallels to major depression.

Authors:  Matthew N Hill; Kim G C Hellemans; Pamela Verma; Boris B Gorzalka; Joanne Weinberg
Journal:  Neurosci Biobehav Rev       Date:  2012-07-07       Impact factor: 8.989

2.  PET imaging of metabotropic glutamate receptor subtype 5 (mGluR5).

Authors:  Dan Li; Hong Shan; Peter Conti; Zibo Li
Journal:  Am J Nucl Med Mol Imaging       Date:  2011-12-15

3.  Alterations of Group I mGluRs and BDNF Associated with Behavioral Abnormity in Prenatally Stressed Offspring Rats.

Authors:  Ning Jia; Qinghong Li; Hongli Sun; Qian Song; Guokui Tang; Qinru Sun; Weixi Wang; Rui Chen; Hui Li; Zhongliang Zhu
Journal:  Neurochem Res       Date:  2015-04-18       Impact factor: 3.996

4.  Elevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depression.

Authors:  Beata Karolewicz; Craig A Stockmeier; Gregory A Ordway
Journal:  Neuropsychopharmacology       Date:  2005-08       Impact factor: 7.853

5.  Stress hormone exposure reduces mGluR5 expression in the nucleus accumbens: functional implications for interoceptive sensitivity to alcohol.

Authors:  Joyce Besheer; Kristen R Fisher; Anel A Jaramillo; Suzanne Frisbee; Reginald Cannady
Journal:  Neuropsychopharmacology       Date:  2014-04-09       Impact factor: 7.853

6.  Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus.

Authors:  A H Iyo; A M Feyissa; A Chandran; M C Austin; S Regunathan; B Karolewicz
Journal:  Neuroscience       Date:  2010-06-23       Impact factor: 3.590

7.  Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study.

Authors:  Chadi G Abdallah; Jonas Hannestad; Graeme F Mason; Sophie E Holmes; Nicole DellaGioia; Gerard Sanacora; Lihong Jiang; David Matuskey; Ritvij Satodiya; Fabrizio Gasparini; Xin Lin; Jonathan Javitch; Beata Planeta; Nabeel Nabulsi; Richard E Carson; Irina Esterlis
Journal:  Biol Psychiatry Cogn Neurosci Neuroimaging       Date:  2017-04-06

8.  Alterations in mGlu5 receptor expression and function in the striatum in a rat depression model.

Authors:  Li-Min Mao; John Q Wang
Journal:  J Neurochem       Date:  2018-02-08       Impact factor: 5.372

9.  Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics.

Authors:  Natalie Matosin; Francesca Fernandez-Enright; Elisabeth Frank; Chao Deng; Jenny Wong; Xu-Feng Huang; Kelly A Newell
Journal:  J Psychiatry Neurosci       Date:  2014-11       Impact factor: 6.186

Review 10.  Metabotropic Glutamatergic Receptor 5 and Stress Disorders: Knowledge Gained From Receptor Imaging Studies.

Authors:  Irina Esterlis; Sophie E Holmes; Priya Sharma; John H Krystal; Christine DeLorenzo
Journal:  Biol Psychiatry       Date:  2017-09-19       Impact factor: 13.382
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