Literature DB >> 119851

The methylated purines of Tetrahymena pyriformis transfer ribonucleic acid.

F P Keegan, J Berech.   

Abstract

By phenol extraction and DEAE cellulose column chromatography, tRNA was isolated from Tetrahymena pyriformis strain GL. Following acid hydrolysis of the tRNA, the methylated purine content was determined by Dowex 50 column chromatography and paper chromatography. The most abundant methylated guanine derivative was found to be N2-DMG. Also present were 1-MG, N2-MG, and 7-MG. The most abundant methylated adenine was found to be 1-MA; no 2-MA was detected. Small amounts of the N6-methyladenines were detected.

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Year:  1979        PMID: 119851     DOI: 10.1111/j.1550-7408.1979.tb04660.x

Source DB:  PubMed          Journal:  J Protozool        ISSN: 0022-3921


  1 in total

1.  Inhibition of growth and purine-metabolizing enzymes of trypanosomid flagellates by N6-methyladenine.

Authors:  L L Nolan; G W Kidder
Journal:  Antimicrob Agents Chemother       Date:  1980-04       Impact factor: 5.191

  1 in total

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