Literature DB >> 11983936

Do defects in ion channel glycosylation set the stage for lethal cardiac arrhythmias?

Harry A Fozzard1, John W Kyle.   

Abstract

Many ion channels are modified by the addition of carbohydrate residues. Fozzard and Kyle discuss evidence that sialic acid residues on glycosylated cardiac sodium and potassium channels may be important for preventing early after-depolarizations that can result in cardiac arrhythmias.

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Year:  2002        PMID： 11983936     DOI： 10.1126/stke.2002.130.pe19

Source DB:  PubMed          Journal:  Sci STKE        ISSN： 1525-8882


  7 in total

1.  Complex N-glycosylation stabilizes surface expression of transient receptor potential melastatin 4b protein.

Authors:  Seung Kyoon Woo; Min Seong Kwon; Alexander Ivanov; Zhihua Geng; Volodymyr Gerzanich; J Marc Simard
Journal:  J Biol Chem       Date:  2013-11-08       Impact factor: 5.157

2.  Sialyltransferase regulates nervous system function in Drosophila.

Authors:  Elena Repnikova; Kate Koles; Michiko Nakamura; Jared Pitts; Haiwen Li; Apoorva Ambavane; Mark J Zoran; Vladislav M Panin
Journal:  J Neurosci       Date:  2010-05-05       Impact factor: 6.167

3.  Selective enrichment of sialic acid-containing glycopeptides using titanium dioxide chromatography with analysis by HILIC and mass spectrometry.

Authors:  Giuseppe Palmisano; Sara Eun Lendal; Kasper Engholm-Keller; Rikke Leth-Larsen; Benjamin L Parker; Martin R Larsen
Journal:  Nat Protoc       Date:  2010-11-18       Impact factor: 13.491

Review 4.  Using iPSC Models to Probe Regulation of Cardiac Ion Channel Function.

Authors:  Arne A N Bruyneel; Wesley L McKeithan; Dries A M Feyen; Mark Mercola
Journal:  Curr Cardiol Rep       Date:  2018-05-25       Impact factor: 2.931

5.  Reference glycan structure libraries of primary human cardiomyocytes and pluripotent stem cell-derived cardiomyocytes reveal cell-type and culture stage-specific glycan phenotypes.

Authors:  Christopher Ashwood; Matthew Waas; Ranjuna Weerasekera; Rebekah L Gundry
Journal:  J Mol Cell Cardiol       Date:  2020-01-21       Impact factor: 5.000

6.  N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels.

Authors:  Desiree A Thayer; Shi-Bing Yang; Yuh Nung Jan; Lily Y Jan
Journal:  J Physiol       Date:  2016-08-02       Impact factor: 5.182

7.  Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2).

Authors:  Aldo A Rodríguez-Menchaca; Scott K Adney; Lei Zhou; Diomedes E Logothetis
Journal:  Front Pharmacol       Date:  2012-09-25       Impact factor: 5.810
  7 in total

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