Literature DB >> 11983914

Differential regulation of the human and murine CD34 genes in hematopoietic stem cells.

Yutaka Okuno1, Hiromi Iwasaki, Claudia S Huettner, Hanna S Radomska, David A Gonzalez, Daniel G Tenen, Koichi Akashi.   

Abstract

Human CD34 (hCD34)-positive cells are used currently as a source for hematopoietic transplantation in humans. However, in steady-state murine hematopoiesis, hematopoietic stem cells (HSCs) with long-term reconstitution activity are found almost exclusively in the murine CD34 (mCD34)-negative to low fraction. To evaluate the possible differences in hCD34 and mCD34 gene expression in hematopoiesis, we made transgenic mouse strains with human genomic P1 artificial chromosome clones spanning the entire hCD34 genomic locus. In all transgenic mouse strains, a vast majority of phenotypic and functional HSC populations including mCD34(-/lo) express the hCD34 transgene. These data strongly support the notion that hCD34(+) human bone marrow cells contain long-term HSCs that can maintain hematopoiesis throughout life.

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Year:  2002        PMID： 11983914      PMCID： PMC122934          DOI： 10.1073/pnas.092027799

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

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Journal:  Nat Med       Date:  2000-11       Impact factor: 53.440

2.  Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell.

Authors:  D S Krause; N D Theise; M I Collector; O Henegariu; S Hwang; R Gardner; S Neutzel; S J Sharkis
Journal:  Cell       Date:  2001-05-04       Impact factor: 41.582

3.  Antigen CD34+ marrow cells engraft lethally irradiated baboons.

Authors:  R J Berenson; R G Andrews; W I Bensinger; D Kalamasz; G Knitter; C D Buckner; I D Bernstein
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4.  Transplantation with selected autologous peripheral blood CD34+Thy1+ hematopoietic stem cells (HSCs) in multiple myeloma: impact of HSC dose on engraftment, safety, and immune reconstitution.

Authors:  M Michallet; T Philip; I Philip; H Godinot; C Sebban; G Salles; A Thiebaut; P Biron; F Lopez; P Mazars; N Roubi; T Leemhuis; E Hanania; C Reading; G Fine; K Atkinson; C Juttner; B Coiffier; D Fière; E Archimbaud
Journal:  Exp Hematol       Date:  2000-07       Impact factor: 3.084

5.  Reciprocal expression of CD38 and CD34 by adult murine hematopoietic stem cells.

Authors:  F Tajima; T Deguchi; J H Laver; H Zeng; M Ogawa
Journal:  Blood       Date:  2001-05-01       Impact factor: 22.113

6.  Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome.

Authors:  R M Kaufman; C T Pham; T J Ley
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7.  Developmental changes of CD34 expression by murine hematopoietic stem cells.

Authors:  T Ito; F Tajima; M Ogawa
Journal:  Exp Hematol       Date:  2000-11       Impact factor: 3.084

8.  CD34 expression by murine hematopoietic stem cells mobilized by granulocyte colony-stimulating factor.

Authors:  F Tajima; T Sato; J H Laver; M Ogawa
Journal:  Blood       Date:  2000-09-01       Impact factor: 22.113

9.  Reversible expression of CD34 by murine hematopoietic stem cells.

Authors:  T Sato; J H Laver; M Ogawa
Journal:  Blood       Date:  1999-10-15       Impact factor: 22.113

10.  Bone marrow cells regenerate infarcted myocardium.

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  20 in total

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Journal:  Mol Biol Cell       Date:  2005-01-05       Impact factor: 4.138

Review 2.  Organ-on-a-chip: development and clinical prospects toward toxicity assessment with an emphasis on bone marrow.

Authors:  Jeehye Kim; Hanna Lee; Šeila Selimović; Robert Gauvin; Hojae Bae
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3.  Mouse models as tools to understand and study BCR-ABL1 diseases.

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4.  CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis.

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Journal:  Am J Respir Crit Care Med       Date:  2011-06-03       Impact factor: 21.405

5.  PU.1 acts as tumor suppressor for myeloma cells through direct transcriptional repression of IRF4.

Authors:  N Ueno; N Nishimura; S Ueno; S Endo; H Tatetsu; S Hirata; H Hata; M Matsuoka; H Mitsuya; Y Okuno
Journal:  Oncogene       Date:  2017-04-03       Impact factor: 9.867

6.  Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.

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Review 7.  Large animal models of hematopoietic stem cell gene therapy.

Authors:  G D Trobridge; H-P Kiem
Journal:  Gene Ther       Date:  2010-04-29       Impact factor: 5.250

8.  Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.

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Journal:  Mol Cell Biol       Date:  2005-04       Impact factor: 4.272

9.  Cellular therapy for repair of cardiac damage after acute myocardial infarction.

Authors:  Matthew M Cook; Katarina Kollar; Gary P Brooke; Kerry Atkinson
Journal:  Int J Cell Biol       Date:  2009-03-29

10.  In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.

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Journal:  Blood       Date:  2012-12-04       Impact factor: 22.113
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