BACKGROUND: Depression is common in later life. AIMS: To determine whether exercise is effective as an adjunct to antidepressant therapy in reducing depressive symptoms in older people. METHOD: Patients were randomised to attend either exercise classes or health education talks for 10 weeks. Assessments were made "blind" at baseline, and at 10 and 34 weeks. The primary outcome was seen with the 17-item Hamilton Rating Scale for Depression (HRSD). Secondary outcomes were seen with the Geriatric Depression Scale, Clinical Global Impression and Patient Global Impression. RESULTS: At 10 weeks a significantly higher proportion of the exercise group (55% v. 33%) experienced a greater than 30% decline in depression according to HRSD (OR=2.51, P=0.05, 95% CI 1.00-6.38). CONCLUSIONS: Because exercise was associated with a modest improvement in depressive symptoms at 10 weeks, older people with poorly responsive depressive disorder should be encouraged to attend group exercise activities.
RCT Entities:
BACKGROUND:Depression is common in later life. AIMS: To determine whether exercise is effective as an adjunct to antidepressant therapy in reducing depressive symptoms in older people. METHOD:Patients were randomised to attend either exercise classes or health education talks for 10 weeks. Assessments were made "blind" at baseline, and at 10 and 34 weeks. The primary outcome was seen with the 17-item Hamilton Rating Scale for Depression (HRSD). Secondary outcomes were seen with the Geriatric Depression Scale, Clinical Global Impression and Patient Global Impression. RESULTS: At 10 weeks a significantly higher proportion of the exercise group (55% v. 33%) experienced a greater than 30% decline in depression according to HRSD (OR=2.51, P=0.05, 95% CI 1.00-6.38). CONCLUSIONS: Because exercise was associated with a modest improvement in depressive symptoms at 10 weeks, older people with poorly responsive depressive disorder should be encouraged to attend group exercise activities.
Authors: Ngaire Kerse; Karen J Hayman; Simon A Moyes; Kathy Peri; Elizabeth Robinson; Anthony Dowell; Gregory S Kolt; C Raina Elley; Simon Hatcher; Liz Kiata; Janine Wiles; Sally Keeling; John Parsons; Bruce Arroll Journal: Ann Fam Med Date: 2010 May-Jun Impact factor: 5.166
Authors: Tracy L Greer; Kolette M Ring; Diane Warden; Bruce D Grannemann; Timothy S Church; Eugene Somoza; Steven N Blair; Jose Szapocznik; Mark Stoutenberg; Chad Rethorst; Robrina Walker; David W Morris; Andrzej S Kosinski; Tiffany Kyle; Bess Marcus; Becca Crowell; Neal Oden; Edward Nunes; Madhukar H Trivedi Journal: J Glob Drug Policy Pract Date: 2012
Authors: Helen Lavretsky; Lily L Alstein; Richard E Olmstead; Linda M Ercoli; Marquertie Riparetti-Brown; Natalie St Cyr; Michael R Irwin Journal: Am J Geriatr Psychiatry Date: 2011-10 Impact factor: 4.105
Authors: Anisha M Suterwala; Chad D Rethorst; Thomas J Carmody; Tracy L Greer; Bruce D Grannemann; Manish Jha; Madhukar H Trivedi Journal: J Clin Psychiatry Date: 2016-08 Impact factor: 4.384
Authors: Arlinda Cerga-Pashoja; David Lowery; Rahul Bhattacharya; Mark Griffin; Steve Iliffe; James Lee; Claire Leonard; Sue Ricketts; Lyn Strother; Fiona Waters; Craig W Ritchie; James Warner Journal: Trials Date: 2010-05-13 Impact factor: 2.279