BACKGROUND/AIMS: This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). METHODS: Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. RESULTS: All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC. CONCLUSIONS: Small duct PSC rarely progresses to large bile duct PSC and it seems to have a benign course in most patients and no development of cholangiocarcinoma was found.
BACKGROUND/AIMS: This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). METHODS: Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. RESULTS: All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC. CONCLUSIONS: Small duct PSC rarely progresses to large bile duct PSC and it seems to have a benign course in most patients and no development of cholangiocarcinoma was found.
Authors: A K Singal; C M Stanca; V Clark; L Dixon; C Levy; J A Odin; M I Fiel; S L Friedman; N Bach Journal: Hepatol Int Date: 2011-03-11 Impact factor: 6.047
Authors: Bettina M Buchholz; Panagis M Lykoudis; Reena Ravikumar; Joerg M Pollok; Giuseppe K Fusai Journal: World J Gastroenterol Date: 2018-07-28 Impact factor: 5.742
Authors: Sigrid Naess; Einar Björnsson; Jarl A Anmarkrud; Said Al Mamari; Brian D Juran; Konstantinos N Lazaridis; Roger Chapman; Annika Bergquist; Espen Melum; Steven G E Marsh; Erik Schrumpf; Benedicte A Lie; Kirsten M Boberg; Tom H Karlsen; Johannes R Hov Journal: Liver Int Date: 2014-03-07 Impact factor: 5.828