Literature DB >> 11983281

Orexin-1 receptor immunoreactivity in chemically identified target neurons in the rat hypothalamus.

Ryusuke Suzuki1, Hisa Shimojima, Hisayuki Funahashi, Shigeo Nakajo, Shuori Yamada, Jian-Lian Guan, Shinobu Tsurugano, Kichiro Uehara, Yoichi Takeyama, Sakae Kikuyama, Seiji Shioda.   

Abstract

Immunohistochemistry and Western blotting were used to determine the distribution of orexin receptors in the rat brain. Strong orexin receptor 1 (OX1R) immunoreactivity was detected in the hypothalamus including the arcuate, ventromedial, and tuberomammillary nuclei that are involved in feeding regulation. The neuropeptide Y- and proopiomelanocortin-containing neurons of the arcuate nucleus, which act to stimulate or to inhibit feeding, respectively, displayed intense OX1R immunoreactivity by double immunostaining. Western blotting analysis yielded a 50-kDa major band of OX1R.

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Year:  2002        PMID： 11983281     DOI： 10.1016/s0304-3940(02)00140-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  8 in total

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5.  Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period.

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6.  Expression and localization of the orexin-1 receptor (OX1R) after traumatic brain injury in mice.

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7.  Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms.

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8.  Variation in the expression of orexin and orexin receptors in the rat hypothalamus during the estrous cycle, pregnancy, parturition, and lactation.

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  8 in total

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