Literature DB >> 11983265

The advantage of early recognition of HIV-infected cells by cytotoxic T-lymphocytes.

Rob A Gruters1, Carel A van Baalen, Albert D M E Osterhaus.   

Abstract

Accumulating evidence indicates that cytotoxic T-lymphocytes (CTL) play an important role in the clearing of primary and control of chronic human immunodeficiency virus (HIV) infection. Here, we discuss recent findings that indicate that the timing of target cell recognition critically contributes to CTL effectiveness. In this light several problems that have troubled CTL research are discussed. The use of early proteins like Tat and Rev is proposed for future vaccines design.

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Year:  2002        PMID： 11983265     DOI： 10.1016/s0264-410x(02)00089-0

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  8 in total

1.  Rapid recruitment of virus-specific CD8 T cells restructures immunodominance during protective secondary responses.

Authors:  Anne E Tebo; Michael J Fuller; Dalia E Gaddis; Kyoko Kojima; Kunal Rehani; Allan J Zajac
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

2.  Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239.

Authors:  Nancy A Wilson; Jason Reed; Gnankang S Napoe; Shari Piaskowski; Andy Szymanski; Jessica Furlott; Edna J Gonzalez; Levi J Yant; Nicholas J Maness; Gemma E May; Taeko Soma; Matthew R Reynolds; Eva Rakasz; Richard Rudersdorf; Adrian B McDermott; David H O'Connor; Thomas C Friedrich; David B Allison; Amit Patki; Louis J Picker; Dennis R Burton; Jing Lin; Lingyi Huang; Deepa Patel; Gwendolyn Heindecker; Jiang Fan; Michael Citron; Melanie Horton; Fubao Wang; Xiaoping Liang; John W Shiver; Danilo R Casimiro; David I Watkins
Journal:  J Virol       Date:  2006-06       Impact factor: 5.103

3.  Viral dynamics model with CTL immune response incorporating antiretroviral therapy.

Authors:  Yan Wang; Yicang Zhou; Fred Brauer; Jane M Heffernan
Journal:  J Math Biol       Date:  2012-08-29       Impact factor: 2.259

4.  A single amino acid difference within the alpha-2 domain of two naturally occurring equine MHC class I molecules alters the recognition of Gag and Rev epitopes by equine infectious anemia virus-specific CTL.

Authors:  Robert H Mealey; Jae-Hyung Lee; Steven R Leib; Matt H Littke; Travis C McGuire
Journal:  J Immunol       Date:  2006-11-15       Impact factor: 5.422

Review 5.  HIV-1 neuroimmunity in the era of antiretroviral therapy.

Authors:  Stephanie D Kraft-Terry; Andrew R Stothert; Shilpa Buch; Howard E Gendelman
Journal:  Neurobiol Dis       Date:  2010-01-04       Impact factor: 5.996

6.  The Mamu B 17-restricted SIV Nef IW9 to TW9 mutation abrogates correct epitope processing and presentation without loss of replicative fitness.

Authors:  Jacob T Minang; Matthew T Trivett; Lori V Coren; Eugene V Barsov; Michael Piatak; Oleg Chertov; Elena Chertova; David E Ott; Claes Ohlen
Journal:  Virology       Date:  2008-03-06       Impact factor: 3.616

7.  Nef-mediated MHC class I down-regulation unmasks clonal differences in virus suppression by SIV-specific CD8(+) T cells independent of IFN-gamma and CD107a responses.

Authors:  Jacob T Minang; Matthew T Trivett; Lori V Coren; Eugene V Barsov; Michael Piatak; David E Ott; Claes Ohlen
Journal:  Virology       Date:  2009-06-24       Impact factor: 3.616

8.  Implications of CTL-mediated killing of HIV-infected cells during the non-productive stage of infection.

Authors:  Christian L Althaus; Rob J De Boer
Journal:  PLoS One       Date:  2011-02-07       Impact factor: 3.240
  8 in total

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