| Literature DB >> 11983252 |
Rama Rao Amara1, Francois Villinger, John D Altman, Shari L Lydy, Shawn P O'Neil, Silvija I Staprans, David C Montefiori, Yan Xu, James G Herndon, Linda S Wyatt, Maria Angelito Candido, Natalia L Kozyr, Patricia L Earl, James M Smith, Hak-Ling Ma, Bennett D Grimm, Michael L Hulsey, Harold M McClure, Janet M McNicholl, Bernard Moss, Harriet L Robinson.
Abstract
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here, we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster has controlled a highly pathogenic immunodeficiency virus challenge in a Rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These highly promising findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the AIDS epidemic.Entities:
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Year: 2002 PMID： 11983252 DOI： 10.1016/s0264-410x(02)00076-2
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641