Literature DB >> 11983153

Nuclear hormone receptors in T lymphocytes.

Astar Winoto1, Dan R Littman.   

Abstract

Among the numerous steroid and orphan nuclear receptors encoded within mammalian genomes, several are involved in regulating immune system functions. We review here recent studies on the glucocorticoid receptor and the orphan receptors Nur77 and RORgamma. These molecules play key roles in the development and the effector functions of T lymphocytes.

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Year:  2002        PMID： 11983153     DOI： 10.1016/s0092-8674(02)00710-9

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  91 in total

1.  Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.

Authors:  Arvind Rajpal; Yuri A Cho; Biana Yelent; Petra H Koza-Taylor; Dongling Li; Elaine Chen; Michael Whang; Chulho Kang; Thomas G Turi; Astar Winoto
Journal:  EMBO J       Date:  2003-12-15       Impact factor: 11.598

2.  Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosis.

Authors:  Jae Myun Lee; Kyoung-Ho Lee; Magdalena Weidner; Barbara A Osborne; S Diane Hayward
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-23       Impact factor: 11.205

3.  Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.

Authors:  Corey Tan; James L Mueller; Mark Noviski; John Huizar; Denise Lau; Alexandra Dubinin; Ari Molofsky; Patrick C Wilson; Julie Zikherman
Journal:  J Immunol       Date:  2019-04-08       Impact factor: 5.422

4.  Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny.

Authors:  Jelena S Bezbradica; Timothy Hill; Aleksandar K Stanic; Luc Van Kaer; Sebastian Joyce
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-25       Impact factor: 11.205

5.  Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma.

Authors:  Serena Ghisletti; Wendy Huang; Sumito Ogawa; Gabriel Pascual; Mu-En Lin; Timothy M Willson; Michael G Rosenfeld; Christopher K Glass
Journal:  Mol Cell       Date:  2007-01-12       Impact factor: 17.970

6.  Enhanced glucocorticoid receptor signaling in T cells impacts thymocyte apoptosis and adaptive immune responses.

Authors:  Jens van den Brandt; Fred Lühder; Kirsty G McPherson; Katrien L de Graaf; Denise Tischner; Stefan Wiehr; Thomas Herrmann; Robert Weissert; Ralf Gold; Holger M Reichardt
Journal:  Am J Pathol       Date:  2007-03       Impact factor: 4.307

7.  Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.

Authors:  Uma K Misra; Steven J Kaczowka; Salvatore V Pizzo
Journal:  Cell Signal       Date:  2007-10-12       Impact factor: 4.315

8.  Role of nuclear receptor NR4A2 in gastrointestinal inflammation and cancers.

Authors:  Yi-Fang Han; Guang-Wen Cao
Journal:  World J Gastroenterol       Date:  2012-12-21       Impact factor: 5.742

9.  The role of the PI3K-AKT kinase pathway in T-cell development beyond the beta checkpoint.

Authors:  Ling Xue; Leslie Chiang; Chulho Kang; Astar Winoto
Journal:  Eur J Immunol       Date:  2008-11       Impact factor: 5.532

10.  HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML.

Authors:  L Zhou; V R Ruvolo; T McQueen; W Chen; I J Samudio; O Conneely; M Konopleva; M Andreeff
Journal:  Leukemia       Date:  2012-12-18       Impact factor: 11.528
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