OBJECTIVES: To examine the relation between left ventricular (LV) diastolic function and glucose metabolism in individuals without previously diagnosed diabetes mellitus. DESIGN: A cross-sectional population-based study. SETTING: A university hospital. SUBJECTS: Thirty-five men and women 56-58 years of age without previously diagnosed diabetes or heart disease. MAIN OUTCOME MEASURES: Left ventricular diastolic function assessed by pulsed Doppler tissue imaging and its relation to fasting plasma glucose, glucose postload and glycated haemoglobin. LV diastolic function was determined by measuring early diastolic filling peak velocity (Em wave cm s-1), late diastolic filling peak velocity (Am wave cm s-1) and their ratio Em/Am. RESULTS: Peak Em velocity, peak Am velocity and their ratio Em/Am correlated with fasting plasma glucose (r=-0.42, P=0.01; r=0.47, P=0.04 and r=-0.53, P=0.001, respectively). There was a correlation between peak Em velocity, the ratio of Em/Am and glycated haemoglobin. LV diastolic function was also related to glucose postload. CONCLUSIONS: Left ventricular diastolic function is related to concentrations of fasting plasma glucose, glucose postload and glycated haemoglobin even below the threshold of diabetes. This indicates that glucose concentrations already in the upper end of the normal range has negative impact on cardiac function.
OBJECTIVES: To examine the relation between left ventricular (LV) diastolic function and glucose metabolism in individuals without previously diagnosed diabetes mellitus. DESIGN: A cross-sectional population-based study. SETTING: A university hospital. SUBJECTS: Thirty-five men and women 56-58 years of age without previously diagnosed diabetes or heart disease. MAIN OUTCOME MEASURES: Left ventricular diastolic function assessed by pulsed Doppler tissue imaging and its relation to fasting plasma glucose, glucose postload and glycated haemoglobin. LV diastolic function was determined by measuring early diastolic filling peak velocity (Em wave cm s-1), late diastolic filling peak velocity (Am wave cm s-1) and their ratio Em/Am. RESULTS: Peak Em velocity, peak Am velocity and their ratio Em/Am correlated with fasting plasma glucose (r=-0.42, P=0.01; r=0.47, P=0.04 and r=-0.53, P=0.001, respectively). There was a correlation between peak Em velocity, the ratio of Em/Am and glycated haemoglobin. LV diastolic function was also related to glucose postload. CONCLUSIONS:Left ventricular diastolic function is related to concentrations of fasting plasma glucose, glucose postload and glycated haemoglobin even below the threshold of diabetes. This indicates that glucose concentrations already in the upper end of the normal range has negative impact on cardiac function.
Authors: Margret Leosdottir; Ronnie Willenheimer; Jonathan Plehn; Rasmus Borgquist; Petri Gudmundsson; Tamara B Harris; Lenore J Launer; Halldora Bjornsdottir; Peter M Nilsson; Vilmundur Gudnason Journal: Am Heart J Date: 2010-03 Impact factor: 4.749
Authors: Silmara Gusso; Teresa E Pinto; James C Baldi; Elizabeth Robinson; Wayne S Cutfield; Paul L Hofman Journal: Diabetes Care Date: 2012-07-06 Impact factor: 19.112
Authors: Christoph Maack; Michael Lehrke; Johannes Backs; Frank R Heinzel; Jean-Sebastien Hulot; Nikolaus Marx; Walter J Paulus; Patrick Rossignol; Heinrich Taegtmeyer; Johann Bauersachs; Antoni Bayes-Genis; Dirk Brutsaert; Heiko Bugger; Kieran Clarke; Francesco Cosentino; Gilles De Keulenaer; Alessandra Dei Cas; Arantxa González; Martin Huelsmann; Guido Iaccarino; Ida Gjervold Lunde; Alexander R Lyon; Piero Pollesello; Graham Rena; Niels P Riksen; Giuseppe Rosano; Bart Staels; Linda W van Laake; Christoph Wanner; Dimitrios Farmakis; Gerasimos Filippatos; Frank Ruschitzka; Petar Seferovic; Rudolf A de Boer; Stephane Heymans Journal: Eur Heart J Date: 2018-12-21 Impact factor: 29.983