BACKGROUND: This investigation assessed the effect of personality disorders (PersDs) on time to remission in patients with generalized anxiety disorder, social phobia, or panic disorder. METHODS: Selected Axis I and II predictors of time to remission during 5 years of follow-up were assessed in 514 patients with 1 or more of these anxiety disorders who participated in the Harvard/Brown Anxiety Research Program, a multisite, prospective, longitudinal, naturalistic study. RESULTS: The presence of a PersD predicted a 30% lower likelihood of generalized anxiety disorder remission, a 39% lower likelihood of social phobia remission, and no difference in likelihood of panic disorder remission. More specifically, a lower likelihood of remission from generalized anxiety disorder was predicted by the presence of avoidant PersD (34% lower) and dependent PersD (14% lower). The presence of avoidant PersD predicted a 41% lower likelihood of social phobia remission. The presence of major depressive disorder did not account for these findings. CONCLUSIONS: Our findings provide new data on the pernicious effect of PersDs on the course of generalized anxiety disorder and social phobia but not panic disorder, suggesting that PersDs have a differential effect on the outcome of anxiety disorders.
BACKGROUND: This investigation assessed the effect of personality disorders (PersDs) on time to remission in patients with generalized anxiety disorder, social phobia, or panic disorder. METHODS: Selected Axis I and II predictors of time to remission during 5 years of follow-up were assessed in 514 patients with 1 or more of these anxiety disorders who participated in the Harvard/Brown Anxiety Research Program, a multisite, prospective, longitudinal, naturalistic study. RESULTS: The presence of a PersD predicted a 30% lower likelihood of generalized anxiety disorder remission, a 39% lower likelihood of social phobia remission, and no difference in likelihood of panic disorder remission. More specifically, a lower likelihood of remission from generalized anxiety disorder was predicted by the presence of avoidant PersD (34% lower) and dependent PersD (14% lower). The presence of avoidant PersD predicted a 41% lower likelihood of social phobia remission. The presence of major depressive disorder did not account for these findings. CONCLUSIONS: Our findings provide new data on the pernicious effect of PersDs on the course of generalized anxiety disorder and social phobia but not panic disorder, suggesting that PersDs have a differential effect on the outcome of anxiety disorders.
Authors: Katharine A Phillips; Maria E Pagano; William Menard; Christina Fay; Robert L Stout Journal: J Nerv Ment Dis Date: 2005-08 Impact factor: 2.254
Authors: Carlos M Grilo; Robert L Stout; John C Markowitz; Charles A Sanislow; Emily B Ansell; Andrew E Skodol; Donna S Bender; Anthony Pinto; M Tracie Shea; Shirley Yen; John G Gunderson; Leslie C Morey; Christopher J Hopwood; Thomas H McGlashan Journal: J Clin Psychiatry Date: 2010-06-15 Impact factor: 4.384
Authors: E B Ansell; A Pinto; M O Edelen; J C Markowitz; C A Sanislow; S Yen; M Zanarini; A E Skodol; M T Shea; L C Morey; J G Gunderson; T H McGlashan; C M Grilo Journal: Psychol Med Date: 2010-09-14 Impact factor: 7.723
Authors: Alvaro Vergés; Matt G Kushner; Kristina M Jackson; Kathleen K Bucholz; Timothy J Trull; Sean P Lane; Kenneth J Sher Journal: J Anxiety Disord Date: 2013-10-14