Literature DB >> 11981449

3-Methylcholanthrene-inducible hepatic DNA adducts: a mechanistic hypothesis linking sequence-specific DNA adducts to sustained cytochrome P4501A1 induction by 3-methylcholanthrene.

Bhagavatula Moorthy1.   

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Year:  2002        PMID: 11981449     DOI: 10.1179/135100002125000127

Source DB:  PubMed          Journal:  Redox Rep        ISSN: 1351-0002            Impact factor:   4.412


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  4 in total

1.  Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo.

Authors:  Weiwu Jiang; Lihua Wang; Sudha R Kondraganti; Inayat S Fazili; Xanthi I Couroucli; Edward A Felix; Bhagavatula Moorthy
Journal:  J Pharmacol Exp Ther       Date:  2010-08-23       Impact factor: 4.030

2.  Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters.

Authors:  Weiwu Jiang; Lihua Wang; Weisheng Zhang; Richard Coffee; Inayat S Fazili; Bhagavatula Moorthy
Journal:  Biochem Biophys Res Commun       Date:  2009-11-11       Impact factor: 3.575

3.  Persistent induction of hepatic and pulmonary phase II enzymes by 3-methylcholanthrene in rats.

Authors:  Sudha R Kondraganti; Weiwu Jiang; Anil K Jaiswal; Bhagavatula Moorthy
Journal:  Toxicol Sci       Date:  2008-01-17       Impact factor: 4.849

4.  Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter.

Authors:  Inayat S Fazili; Weiwu Jiang; Lihua Wang; Edward A Felix; Tanvir Khatlani; Xavier Coumoul; Robert Barouki; Bhagavatula Moorthy
Journal:  J Pharmacol Exp Ther       Date:  2010-01-05       Impact factor: 4.030

  4 in total

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