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Literature DB >> 1198096

Alcoholic hepatomegaly: accumulation of protein in the liver.

E Baraona, M A Leo, S A Borowsky, C S Lieber.

Abstract

The hepatomegaly that appears after long-term feeding of ethanol results in accumulation of protein that is quantitatively as important as the increase in lipid. The bulk of protein accumulated in the soluble fraction of the cell. Hepatic albumin and transferrin concentrations increase and colchicine-binding protein decreases, thus suggesting an intrahepatic retention of export proteins.

Entities: Chemical Disease Gene

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Year: 1975 PMID： 1198096 DOI： 10.1126/science.1198096

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

30 in total

Review 1. Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis.

Authors: Natalia A Osna; Paul G Thomes; Terrence M Donohue
Journal: World J Gastroenterol Date: 2011-05-28 Impact factor: 5.742

2. Studies on the persistence of differentiated functions in rat hepatocytes set into primary tissue culture. II. Production of specific exportable proteins and the effect of purine cyclic nucleotides: an immunofluorescent study.

Authors: U Armato; P G Andreis; E Draghi; E Negri; L Mengato; G Neri
Journal: In Vitro Date: 1978-10

9. S-adenosyl-L-methionine co-administration prevents the ethanol-elicited dissociation of hepatic mitochondrial ribosomes in male rats.

Authors: Peter Sykora; Kusum K Kharbanda; Sara E Crumm; Alan Cahill
Journal: Alcohol Clin Exp Res Date: 2008-09-30 Impact factor: 3.455

10. Clinical detection of the hepatic lesion of pericentral sclerosis in chronic alcoholics.

Authors: Y Kaku; Y Hasumura; J Takeuchi
Journal: Gut Date: 1982-03 Impact factor: 23.059

Alcoholic hepatomegaly: accumulation of protein in the liver.

Review 1. Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis.

2. Studies on the persistence of differentiated functions in rat hepatocytes set into primary tissue culture. II. Production of specific exportable proteins and the effect of purine cyclic nucleotides: an immunofluorescent study.

Review 3. The Activation and Function of Autophagy in Alcoholic Liver Disease.

Review 4. Role of autophagy in alcohol and drug-induced liver injury.

5. Role of autophagy in liver physiology and pathophysiology.

Review 6. Pathologic aspects of cirrhosis. A review.

7. Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells.

Review 8. Autophagy and ethanol-induced liver injury.

9. S-adenosyl-L-methionine co-administration prevents the ethanol-elicited dissociation of hepatic mitochondrial ribosomes in male rats.

10. Clinical detection of the hepatic lesion of pericentral sclerosis in chronic alcoholics.