Literature DB >> 1197921

Effect of plasma protein binding on the anticoagulant action of warfarin in rats.

A Yacobi, G Levy.   

Abstract

The relationships between the anticoagulant effect and the concentrations of free and total (sum of free and protein-bound) warfarin in plasma were determined in rats following intravenous administration of single doses of racemic warfarin or S(-)-warfarin. The concentration of total warfarin required to elicit a defined anticoagulant effect varied widely between animals while the concentration of free warfarin showed much less variation. This indicates that the anticoagulant effect of warfarin is a function of its free concentration in plasma.

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Year:  1975        PMID： 1197921

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  5 in total

1.  Protein binding of warfarin enantiomers in serum of humans and rats.

Authors:  A Yacobi; G Levy
Journal:  J Pharmacokinet Biopharm       Date:  1977-04

2.  Effect of serum protein binding on pharmacokinetics and anticoagulant activity of phenprocoumon in rats.

Authors:  D Trenk; E Jähnchen
Journal:  J Pharmacokinet Biopharm       Date:  1980-04

3.  Effects of etravirine on the pharmacokinetics and pharmacodynamics of warfarin in rats.

Authors:  J John; M John; L Wu; C Hsiao; C V Abobo; D Liang
Journal:  Br J Pharmacol       Date:  2013-04       Impact factor: 8.739

Review 4.  Protein binding as a primary determinant of the clinical pharmacokinetic properties of non-steroidal anti-inflammatory drugs.

Authors:  J H Lin; D M Cocchetto; D E Duggan
Journal:  Clin Pharmacokinet       Date:  1987-06       Impact factor: 6.447

5.  Variation in the binding affinity of warfarin and phenprocoumon to human serum albumin in relation to surgery.

Authors:  H Vorum; H R Jørgensen; R Brodersen
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953
  5 in total

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