Literature DB >> 11979111

Implications of antiretroviral resistance on viral fitness.

M Nijhuis1, S Deeks, C Boucher.   

Abstract

Treatment of HIV infected patients with antiretroviral drugs often results in the emergence of virus variants with reduced sensitivity to these drugs. However, the viral load often remains partially suppressed below pretherapy levels, which might be explained by a reduced fitness of the drug resistant viral population. This review describes the effects of antiretroviral resistance development on the fitness of the viral population and its clinical implications.

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Year:  2001        PMID： 11979111     DOI： 10.1097/00001432-200102000-00005

Source DB:  PubMed          Journal:  Curr Opin Infect Dis        ISSN： 0951-7375            Impact factor:   4.915


  37 in total

1.  Detection of minority resistance during early HIV-1 infection: natural variation and spurious detection rather than transmission and evolution of multiple viral variants.

Authors:  Sara Gianella; Wayne Delport; Mary E Pacold; Jason A Young; Jun Yong Choi; Susan J Little; Douglas D Richman; Sergei L Kosakovsky Pond; Davey M Smith
Journal:  J Virol       Date:  2011-06-01       Impact factor: 5.103

2.  Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture.

Authors:  Carrie Dykes; Jiong Wang; Xia Jin; Vicente Planelles; Dong Sung An; Amanda Tallo; Yangxin Huang; Hulin Wu; Lisa M Demeter
Journal:  J Clin Microbiol       Date:  2006-06       Impact factor: 5.948

3.  The fitness cost of mutations associated with human immunodeficiency virus type 1 drug resistance is modulated by mutational interactions.

Authors:  Mian-er Cong; Walid Heneine; J Gerardo García-Lerma
Journal:  J Virol       Date:  2006-12-27       Impact factor: 5.103

4.  Modeling within-host HIV-1 dynamics and the evolution of drug resistance: trade-offs between viral enzyme function and drug susceptibility.

Authors:  Libin Rong; Michael A Gilchrist; Zhilan Feng; Alan S Perelson
Journal:  J Theor Biol       Date:  2007-04-19       Impact factor: 2.691

5.  Using mathematical modeling and control to develop structured treatment interruption strategies for HIV infection.

Authors:  Eric S Rosenberg; Marie Davidian; H Thomas Banks
Journal:  Drug Alcohol Depend       Date:  2007-02-05       Impact factor: 4.492

6.  Phylogenetic analysis of population-based and deep sequencing data to identify coevolving sites in the nef gene of HIV-1.

Authors:  Art F Y Poon; Luke C Swenson; Winnie W Y Dong; Wenjie Deng; Sergei L Kosakovsky Pond; Zabrina L Brumme; James I Mullins; Douglas D Richman; P Richard Harrigan; Simon D W Frost
Journal:  Mol Biol Evol       Date:  2009-12-02       Impact factor: 16.240

7.  Compensation of fitness costs and reversibility of antibiotic resistance mutations.

Authors:  Pia Schulz zur Wiesch; Jan Engelstädter; Sebastian Bonhoeffer
Journal:  Antimicrob Agents Chemother       Date:  2010-02-22       Impact factor: 5.191

8.  Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation.

Authors:  Miguel E Quiñones-Mateu; Mahlet Tadele; Mariona Parera; Antonio Mas; Jan Weber; Héctor R Rangel; Bikram Chakraborty; Bonaventura Clotet; Esteban Domingo; Luis Menéndez-Arias; Miguel A Martínez
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

9.  High prevalence of M184 mutation among patients with viroimmunologic discordant responses to highly active antiretroviral therapy and outcomes after change of therapy guided by genotypic analysis.

Authors:  Emanuele Nicastri; Loredana Sarmati; Gabriella d'Ettorre; Saverio G Parisi; Lucia Palmisano; Clementina Galluzzo; Marco Montano; Ilaria Uccella; Roberta Amici; Francesca Gatti; Vincenzo Vullo; Ercole Concia; Stefano Vella; Massimo Andreoni
Journal:  J Clin Microbiol       Date:  2003-07       Impact factor: 5.948

10.  RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy.

Authors:  Wei Shao; Mary Kearney; Frank Maldarelli; John W Mellors; Robert M Stephens; Jeffrey D Lifson; Vineet N KewalRamani; Zandrea Ambrose; John M Coffin; Sarah E Palmer
Journal:  Retrovirology       Date:  2009-11-04       Impact factor: 4.602
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