Effects of stereochemical aspects on drug interaction in pharmacokinetics.

Recent literatures on enantiomer/enantiomer and enantiomer/coadministered drug interactions in pharmacokinetics were reviewed. The clinical significance of introducing the concept of stereoselectivity into pharmacokinetic interaction study cannot be overestimated, such as avoiding interaction-based adverse reactions, increasing therapeutic index, resolving the apparent anomaly in the plasma concentration-effect relationship and providing starting point of investigation into drug disposition, etc. Study in this respect should be enhanced.