| Literature DB >> 11976456 |
Douglas F Levinson1, Peter A Holmans, Claudine Laurent, Brien Riley, Ann E Pulver, Pablo V Gejman, Sibylle G Schwab, Nigel M Williams, Michael J Owen, Dieter B Wildenauer, Alan R Sanders, Gerald Nestadt, Bryan J Mowry, Brandon Wormley, Stephanie Bauché, Stephane Soubigou, Robert Ribble, Deborah A Nertney, Kung Yee Liang, Laura Martinolich, Wolfgang Maier, Nadine Norton, Hywel Williams, Margot Albus, Eric B Carpenter, Nicola DeMarchi, Kelly R Ewen-White, Dermot Walsh, Maurice Jay, Jean-François Deleuze, F Anthony O'Neill, George Papadimitriou, Ann Weilbaecher, Bernard Lerer, Michael C O'Donovan, Dimitris Dikeos, Jeremy M Silverman, Kenneth S Kendler, Jacques Mallet, Raymond R Crowe, Marilyn Walters.
Abstract
Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.Entities:
Mesh：
Year: 2002 PMID： 11976456 DOI： 10.1126/science.1069914
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728