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Literature DB >> 11976013

Therapeutic applications of microbubbles.

Evan C Unger¹, Terry Onichi Matsunaga, Thomas McCreery, Patricia Schumann, Robert Sweitzer, Rachel Quigley.

Abstract

Microbubbles, currently used as contrast agents have potential therapeutic applications. Microbubbles, upon insonation of sufficiently intense ultrasound will cavitate. Cavitation with microbubbles can be used to dissolve blood clots or deliver drugs. Targeting ligands and drugs can be incorporated into microbubbles to make highly specific diagnostic and therapeutic agents for activation with ultrasound. In this paper I will review some of these potential applications and experimental results using such agents for thrombolysis, drug and gene delivery.

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Year: 2002 PMID： 11976013 DOI： 10.1016/s0720-048x(01)00455-7

Source DB: PubMed Journal: Eur J Radiol ISSN： 0720-048X Impact factor: 3.528

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Cited

44 in total

10. Novel ultrasound-targeted microbubble destruction mediated short hairpin RNA plasmid transfection targeting survivin inhibits gene expression and induces apoptosis of HeLa cells.

Authors: Zhiyi Chen; Kun Liang; Mingxing Xie; Xinfang Wang; Qing Lü; Jing Zhang
Journal: Mol Biol Rep Date: 2008-11-09 Impact factor: 2.316

Therapeutic applications of microbubbles.

Review 1. Contrast-enhanced and targeted ultrasound.

2. The role of acoustofluidics in targeted drug delivery.

Review 3. [Ultrasound contrast agents--physical basics].

4. Microbubble-enhanced ultrasound exposure improves gene transfer in vascular endothelial cells.

5. Cavitation threshold of microbubbles in gel tunnels by focused ultrasound.

6. Ultrasound-mediated microbubble destruction facilitates gene transfection in rat C6 glioma cells.

7. Modeling transmembrane transport through cell membrane wounds created by acoustic cavitation.

8. Stability of microbubbles prepared by co-axial electrohydrodynamic atomisation.

9. Mechanisms of microbubble-vessel interactions and induced stresses: a numerical study.

10. Novel ultrasound-targeted microbubble destruction mediated short hairpin RNA plasmid transfection targeting survivin inhibits gene expression and induces apoptosis of HeLa cells.