BACKGROUND: Hypercapnia and local pressure effects unique to CO(2) base minimally invasive surgery alter renal blood flow. We have demonstrated laparoscopic antireflux surgery to have an additional impact upon hemodynamics (decreased cardiac output), potentially extending known effects upon renal blood flow. METHODS: We measured renal blood flow with radioactive microspheres during laparoscopic antireflux surgery in a porcine model. Six pigs were anesthetized, monitoring lines were placed, and microspheres injected five time points associated with a laparoscopic antireflux operation. After euthanasia kidneys were retrieved and fixed, and representative samples counted for radioactivity specific for each of the five time points. RESULTS: The greatest reduction in renal blood flow was 36% below baseline (p<0.05). Concurrently, cardiac output had a maximum reduction of 39%. CONCLUSIONS: Laparoscopic Nissen fundoplication in this pig model is associated with a significant reduction in renal blood flow, probably related to reduction in cardiac output. Caution is warranted when considering laparoscopic antireflux surgery in patients with a compromised renal blood flow.
BACKGROUND:Hypercapnia and local pressure effects unique to CO(2) base minimally invasive surgery alter renal blood flow. We have demonstrated laparoscopic antireflux surgery to have an additional impact upon hemodynamics (decreased cardiac output), potentially extending known effects upon renal blood flow. METHODS: We measured renal blood flow with radioactive microspheres during laparoscopic antireflux surgery in a porcine model. Six pigs were anesthetized, monitoring lines were placed, and microspheres injected five time points associated with a laparoscopic antireflux operation. After euthanasia kidneys were retrieved and fixed, and representative samples counted for radioactivity specific for each of the five time points. RESULTS: The greatest reduction in renal blood flow was 36% below baseline (p<0.05). Concurrently, cardiac output had a maximum reduction of 39%. CONCLUSIONS: Laparoscopic Nissen fundoplication in this pig model is associated with a significant reduction in renal blood flow, probably related to reduction in cardiac output. Caution is warranted when considering laparoscopic antireflux surgery in patients with a compromised renal blood flow.
Authors: S V Demyttenaere; L S Feldman; S Bergman; S Gholoum; C Moriello; B Unikowsky; S Fraser; F Carli; G M Fried Journal: Surg Endosc Date: 2005-12-09 Impact factor: 4.584
Authors: Chris Westgarth-Taylor; Leonnie de Lijster; Guido van Bogerijen; Alastair J W Millar; Jonathan Karpelowsky Journal: Surg Endosc Date: 2013-04-19 Impact factor: 4.584
Authors: M F McGee; M J Rosen; J Marks; A Chak; R Onders; A Faulx; A Ignagni; S Schomisch; J Ponsky Journal: Surg Endosc Date: 2007-02-07 Impact factor: 3.453
Authors: María F Martín-Cancho; Verónica Crisóstomo; Federico Soria; Carmen Calles; Francisco M Sánchez-Margallo; Idoia Díaz-Güemes; Jesús Usón-Gargallo Journal: Anesthesiol Res Pract Date: 2008-03-27