B Demoré1, J Vigneron, A Perrin, M A Hoffman, M Hoffman. 1. Pharmacie Brabois Adultes - Centre Hospitalier Universitaire de Nancy, Allée du Morvan, Vandoeuvre-les-Nancy, France. bdemore@club-internet.fr
Abstract
OBJECTIVE: To compare the release of diethylhexyl phthalate (DEHP) from polyvinyl chloride (PVC) bags from four different manufacturers into intravenous etoposide solutions. METHOD: Etoposide solutions, 0.4 mg/mL, containing the vehicle polysorbate 80 were prepared in 5% dextrose or 0.9% sodium chloride injection PVC bags and stored at room temperature for 24 h. DEHP content was analysed by high-performance liquid chromatography. RESULTS: Substantial amounts of DEHP (up to 20 microg/mL at room temperature) leached into the etoposide solutions. However, no significant differences were found in the amounts of DEHP leached into the etoposide infusion solutions prepared using either 5% dextrose or 0.9% sodium chloride injection and stored in the four different containers. CONCLUSION: To minimize patient exposure o DEHP, etoposide solutions should ideally be stored in a glass or polyolefin container.
OBJECTIVE: To compare the release of diethylhexyl phthalate (DEHP) from polyvinyl chloride (PVC) bags from four different manufacturers into intravenous etoposide solutions. METHOD:Etoposide solutions, 0.4 mg/mL, containing the vehicle polysorbate 80 were prepared in 5% dextrose or 0.9% sodium chloride injection PVC bags and stored at room temperature for 24 h. DEHP content was analysed by high-performance liquid chromatography. RESULTS: Substantial amounts of DEHP (up to 20 microg/mL at room temperature) leached into the etoposide solutions. However, no significant differences were found in the amounts of DEHP leached into the etoposide infusion solutions prepared using either 5% dextrose or 0.9% sodium chloride injection and stored in the four different containers. CONCLUSION: To minimize patient exposure o DEHP, etoposide solutions should ideally be stored in a glass or polyolefin container.
Authors: Judy Y Chang; Nina J Xiao; Min Zhu; Jennifer Zhang; Ed Hoff; Stephen J Russell; Viswanatham Katta; Steven J Shire Journal: Pharm Res Date: 2010-06-30 Impact factor: 4.200