Literature DB >> 11975626

Stereospecific beta-lithiation of oxazolinyloxiranes: synthesis of alpha,beta-epoxy-gamma-butyrolactones.

Vito Capriati1, Leonardo Degennaro, Raffaele Favia, Saverio Florio, Renzo Luisi.   

Abstract

[reaction: see text]. Stereospecific beta-lithiation of beta-aryl-substituted oxazolinyloxiranes is described. The trapping reaction of such reactive intermediates with carbonyl compounds gave alpha,beta-epoxy-gamma-butyrolactones after deblocking of the oxazoline moiety. This methodology has been also extended to the synthesis of optically active alpha,beta-epoxy-gamma-butyrolactones.

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Year:  2002        PMID: 11975626     DOI: 10.1021/ol025781i

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  Stereo- and Enantioselective Addition of Organolithiums to 2-Oxazolinylazetidines as a Synthetic Route to 2-Acylazetidines.

Authors:  Pantaleo Musci; Marco Colella; Flavio Fanelli; Angela Altomare; Luisa Pisano; Claudia Carlucci; Renzo Luisi; Leonardo Degennaro
Journal:  Front Chem       Date:  2019-09-10       Impact factor: 5.221

  1 in total

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