| Literature DB >> 11975608 |
Mahesh K Lakshman1, Paul F Thomson, Mark A Nuqui, John H Hilmer, Nonka Sevova, Bill Boggess.
Abstract
[reaction: see text]. The O6-(2-mesitylenesulfonyl) derivative of 2'-deoxyguanosine undergoes a facile palladium-mediated C-C cross-coupling with arylboronic acids. Demonstrating the general applicability of this method, the synthesis of a previously undescribed class of 2-amino-6-arylpurine 2'-deoxynucleosides has been accomplished. The study also describes an evaluation of the O6-(2,4,6-triisopropylphenylsulfonyl) and the O6-(4-toluenesulfonyl) derivatives for the cross-coupling.Entities:
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Year: 2002 PMID： 11975608 DOI： 10.1021/ol025673w
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005