Literature DB >> 11973327

Invasive filamentous growth of Candida albicans is promoted by Czf1p-dependent relief of Efg1p-mediated repression.

Angela D Giusani1, Marcelo Vinces, Carol A Kumamoto.   

Abstract

Filamentation of Candida albicans occurs in response to many environmental cues. During growth within matrix, Efg1p represses filamentation and Czf1p relieves this repression. We propose that Czf1p interacts with Efg1p, altering its function. The complex regulation of filamentation may reflect the versatility of C. albicans as a pathogen.

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Year:  2002        PMID： 11973327      PMCID： PMC1462044     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  22 in total

1.  Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4p.

Authors:  E Leberer; K Ziegelbauer; A Schmidt; D Harcus; D Dignard; J Ash; L Johnson; D Y Thomas
Journal:  Curr Biol       Date:  1997-08-01       Impact factor: 10.834

2.  A novel function for Myc: inhibition of C/EBP-dependent gene activation.

Authors:  S Mink; B Mutschler; R Weiskirchen; K Bister; K H Klempnauer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

3.  Nonfilamentous C. albicans mutants are avirulent.

Authors:  H J Lo; J R Köhler; B DiDomenico; D Loebenberg; A Cacciapuoti; G R Fink
Journal:  Cell       Date:  1997-09-05       Impact factor: 41.582

4.  Candida albicans--do mycelia matter?

Authors:  J F Ryley; N G Ryley
Journal:  J Med Vet Mycol       Date:  1990

5.  Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast.

Authors:  P James; J Halladay; E A Craig
Journal:  Genetics       Date:  1996-12       Impact factor: 4.562

6.  The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter.

Authors:  L M Facchini; S Chen; W W Marhin; J N Lear; L Z Penn
Journal:  Mol Cell Biol       Date:  1997-01       Impact factor: 4.272

7.  Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development.

Authors:  J R Köhler; G R Fink
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-12       Impact factor: 11.205

8.  Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans.

Authors:  E Leberer; D Harcus; I D Broadbent; K L Clark; D Dignard; K Ziegelbauer; A Schmidt; N A Gow; A J Brown; D Y Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-12       Impact factor: 11.205

9.  Critical role of germ tube formation in the pathogenesis of candidal vaginitis.

Authors:  J D Sobel; G Muller; H R Buckley
Journal:  Infect Immun       Date:  1984-06       Impact factor: 3.441

10.  Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog.

Authors:  H Liu; J Köhler; G R Fink
Journal:  Science       Date:  1994-12-09       Impact factor: 47.728
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  46 in total

1.  APSES proteins regulate morphogenesis and metabolism in Candida albicans.

Authors:  Thomas Doedt; Shankarling Krishnamurthy; Dirk P Bockmühl; Bernd Tebarth; Christian Stempel; Claire L Russell; Alistair J P Brown; Joachim F Ernst
Journal:  Mol Biol Cell       Date:  2004-07       Impact factor: 4.138

2.  Regulation of the hypoxic response in Candida albicans.

Authors:  John M Synnott; Alessandro Guida; Siobhan Mulhern-Haughey; Desmond G Higgins; Geraldine Butler
Journal:  Eukaryot Cell       Date:  2010-09-24

3.  Expression of the Candida albicans morphogenesis regulator gene CZF1 and its regulation by Efg1p and Czf1p.

Authors:  Marcelo D Vinces; Christopher Haas; Carol A Kumamoto
Journal:  Eukaryot Cell       Date:  2006-05

4.  Gpa2, a G-protein alpha subunit required for hyphal development in Candida albicans.

Authors:  Cristina Sánchez-Martínez; José Pérez-Martín
Journal:  Eukaryot Cell       Date:  2002-12

5.  Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth.

Authors:  Stephen W Martin; Lois M Douglas; James B Konopka
Journal:  Eukaryot Cell       Date:  2005-07

Review 6.  Regulatory circuitry governing fungal development, drug resistance, and disease.

Authors:  Rebecca S Shapiro; Nicole Robbins; Leah E Cowen
Journal:  Microbiol Mol Biol Rev       Date:  2011-06       Impact factor: 11.056

7.  Candida albicans Sfl1 suppresses flocculation and filamentation.

Authors:  Janine Bauer; Jürgen Wendland
Journal:  Eukaryot Cell       Date:  2007-08-31

8.  Expression of UME6, a key regulator of Candida albicans hyphal development, enhances biofilm formation via Hgc1- and Sun41-dependent mechanisms.

Authors:  Mohua Banerjee; Priya Uppuluri; Xiang R Zhao; Patricia L Carlisle; Geethanjali Vipulanandan; Cristina C Villar; José L López-Ribot; David Kadosh
Journal:  Eukaryot Cell       Date:  2012-12-07

9.  Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection.

Authors:  Stephen P Saville; Anna L Lazzell; Carlos Monteagudo; Jose L Lopez-Ribot
Journal:  Eukaryot Cell       Date:  2003-10

10.  Transcription profiling of cyclic AMP signaling in Candida albicans.

Authors:  Doreen Harcus; André Nantel; Anne Marcil; Tracey Rigby; Malcolm Whiteway
Journal:  Mol Biol Cell       Date:  2004-07-21       Impact factor: 4.138
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