Literature DB >> 11973127

Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?

Eric Vivier1, Elena Tomasello, Pascale Paul.   

Abstract

NKG2D is an activating cell surface receptor expressed on a wide range of immune effector cells including NK cells, NKT cells, gammadelta T cells as well as CD8(+) alphabeta T cells. Recent data indicate two major features: first, that human (MICA, MICB and ULBP) and mouse (Rae1 and H60) NKG2D ligands can be induced and/or upregulated upon cellular distress; and second, that on T cells NKG2D serves as a co-stimulation molecule for TCR triggering, whereas on NK cells NKG2D may act as a primary recognition structure.

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Year:  2002        PMID： 11973127     DOI： 10.1016/s0952-7915(02)00337-0

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  44 in total

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