J Simpson1, J H Scholefield, R C Spiller. 1. Departments of Surgery and Gastroenterology, University Hospital, Nottingham, UK. j.simpson@nottingham.ac.uk
Abstract
BACKGROUND: Diverticula are herniations through the colonic wall and are therefore likely to be due to a weakness within the wall, an alteration in intracolonic pressures or a combination of these factors. This article reviews these aspects in relation to the pathogenesis of colonic diverticula. METHODS: Medline and Science Citation Index searches were performed to locate English language articles relating to the pathogenesis of colonic diverticulosis published since 1960. Manual cross-referencing was also performed and some historical articles were included. RESULTS AND CONCLUSION: Several theories now exist about the development of colonic diverticula. The majority of the evidence suggests that the morphological changes are the response to a lifelong consumption of a low-residue diet. However, there are complex relations between colonic structure, motility and dietary factors, and it is likely that all of these (and possibly genetic influences) play a role in the pathogenesis to a greater or lesser degree.
BACKGROUND: Diverticula are herniations through the colonic wall and are therefore likely to be due to a weakness within the wall, an alteration in intracolonic pressures or a combination of these factors. This article reviews these aspects in relation to the pathogenesis of colonic diverticula. METHODS: Medline and Science Citation Index searches were performed to locate English language articles relating to the pathogenesis of colonic diverticulosis published since 1960. Manual cross-referencing was also performed and some historical articles were included. RESULTS AND CONCLUSION: Several theories now exist about the development of colonic diverticula. The majority of the evidence suggests that the morphological changes are the response to a lifelong consumption of a low-residue diet. However, there are complex relations between colonic structure, motility and dietary factors, and it is likely that all of these (and possibly genetic influences) play a role in the pathogenesis to a greater or lesser degree.
Authors: Bryan P Kline; Kathleen M Schieffer; Christine S Choi; Tara Connelly; Jeffrey Chen; Leonard Harris; Sue Deiling; Gregory S Yochum; Walter A Koltun Journal: Dig Dis Sci Date: 2018-12-03 Impact factor: 3.199
Authors: A T P M Claassen; P E C Mourad-Baars; M L Mearin; Y Hilhorst-Hofstee; A Gerritsen van der Hoop Journal: Int J Colorectal Dis Date: 2005-01-28 Impact factor: 2.571