Literature DB >> 11971961

A testicular germ cell-associated serine-threonine kinase, MAK, is dispensable for sperm formation.

Yoichi Shinkai1, Hideo Satoh, Naoki Takeda, Mikiko Fukuda, Emiko Chiba, Tomoya Kato, Takashi Kuramochi, Yoshihiko Araki.   

Abstract

A member of the mitogen-activated protein kinase superfamily, MAK, has been proposed to have an important role in spermatogenesis, since Mak gene expression is highly restricted to testicular germ cells. To assess the biological function of MAK, we have established MAK-deficient (Mak(-/-)) mice. Mak(-/-) mice developed normally, and no gross abnormalities were observed. Spermatogenesis of the Mak(-/-) mice was also intact, and most of the mice were fertile. However, Mak(-/-) male-derived litter sizes and their sperm motility in vitro were mildly reduced. These data show that function of MAK is not essential for spermatogenesis and male fertility.

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Year:  2002        PMID： 11971961      PMCID： PMC133803          DOI： 10.1128/MCB.22.10.3276-3280.2002

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  22 in total

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