Literature DB >> 11971001

Regulation of human Fc epsilon RI alpha-chain gene expression by multiple transcription factors.

Chiharu Nishiyama1, Masanari Hasegawa, Makoto Nishiyama, Kyoko Takahashi, Yushiro Akizawa, Toyokazu Yokota, Ko Okumura, Hideoki Ogawa, Chisei Ra.   

Abstract

Transcriptional regulation of the gene-encoding human Fc epsilon RI alpha-chain was analyzed in detail. EMSA revealed that either YY1 or PU.1 bound to the region close to that recognized by Elf-1. The alpha-chain promoter activity was up-regulated approximately 2-fold by exogenously expressed YY1 or PU.1 and approximately 7-fold by GATA-1, respectively, in KU812 cells. In contrast, coexpression of GATA-1 with either of PU.1 or YY1 dramatically activated the promoter approximately 41- or approximately 27-fold, respectively. Especially synergic activation by GATA-1 and PU.1 was surprising, because these transcription factors are known to inhibit the respective transactivating activities of each other. These up-regulating effects of PU.1 and YY1 with GATA-1 were inhibited by overexpression of Elf-1, indicating that Elf-1 serves as a repressor for the alpha-chain gene expression. Transcriptional regulation of the alpha-chain gene through four transcriptional factors is discussed.

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Year:  2002        PMID： 11971001     DOI： 10.4049/jimmunol.168.9.4546

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  18 in total

1.  Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells.

Authors:  Naomi Shimokawa; Chiharu Nishiyama; Nobuhiro Nakano; Keiko Maeda; Ryuyo Suzuki; Mutsuko Hara; Tatsuo Fukai; Tomoko Tokura; Hiroaki Miyajima; Atsuhito Nakao; Hideoki Ogawa; Ko Okumura
Journal:  Immunogenetics       Date:  2010-04-20       Impact factor: 2.846

2.  GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression.

Authors:  Yosuke Baba; Keiko Maeda; Takuya Yashiro; Eisuke Inage; Kazumi Kasakura; Ryuyo Suzuki; François Niyonsaba; Mutsuko Hara; Atsushi Tanabe; Hideoki Ogawa; Ko Okumura; Yoshikazu Ohtsuka; Toshiaki Shimizu; Chiharu Nishiyama
Journal:  J Biol Chem       Date:  2012-08-03       Impact factor: 5.157

3.  Restoring PU.1 induces apoptosis and modulates viral transactivation via interferon-stimulated genes in primary effusion lymphoma.

Authors:  H Goto; R Kariya; E Kudo; Y Okuno; K Ueda; H Katano; S Okada
Journal:  Oncogene       Date:  2017-05-08       Impact factor: 9.867

4.  Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: molecular cloning of rat Icsbp (Irf-8) cDNA.

Authors:  Nobuhiro Nakano; Chiharu Nishiyama; Nobutaka Masuoka; Makoto Nishiyama; Hisakazu Yamane; Ko Okumura; Hideoki Ogawa
Journal:  Immunogenetics       Date:  2005-02-02       Impact factor: 2.846

Review 5.  Development, migration, and survival of mast cells.

Authors:  Yoshimichi Okayama; Toshiaki Kawakami
Journal:  Immunol Res       Date:  2006       Impact factor: 2.829

6.  Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity.

Authors:  Taisuke Sawada; Chiharu Nishiyama; Takuma Kishi; Tomonari Sasazuki; Sachiko Komazawa-Sakon; Xin Xue; Jiang-Hu Piao; Hideko Ogata; Jun-ichi Nakayama; Tomohiko Taki; Yasuhide Hayashi; Mamoru Watanabe; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Journal:  J Biol Chem       Date:  2008-07-30       Impact factor: 5.157

7.  Transcriptional regulation of Elf-1: locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturation.

Authors:  Fernando J Calero-Nieto; Andrew D Wood; Nicola K Wilson; Sarah Kinston; Josette-Renée Landry; Berthold Göttgens
Journal:  Nucleic Acids Res       Date:  2010-06-04       Impact factor: 16.971

8.  Suppressive effect of Elf-1 on FcepsilonRI alpha-chain expression in primary mast cells.

Authors:  Qing-Hui Wang; Chiharu Nishiyama; Nobuhiro Nakano; Naomi Shimokawa; Mutsuko Hara; Shunsuke Kanada; Hideoki Ogawa; Ko Okumura
Journal:  Immunogenetics       Date:  2008-07-16       Impact factor: 2.846

9.  FcepsilonRIalpha gene -18483A>C polymorphism affects transcriptional activity through YY1 binding.

Authors:  Daniel P Potaczek; Keiko Maeda; Qing-Hui Wang; Nobuhiro Nakano; Shunsuke Kanada; Ewa Stepien; Agnieszka Branicka; Tatsuo Fukai; Mutsuko Hara; Tomoko Tokura; Hideoki Ogawa; Anetta Undas; Ko Okumura; Chiharu Nishiyama
Journal:  Immunogenetics       Date:  2009-08-14       Impact factor: 2.846

10.  PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells.

Authors:  Yuang-Taung Juang; Ying Wang; Guisen Jiang; Hai-Bin Peng; Sukran Ergin; Michelle Finnell; Abigail Magilavy; Vasileios C Kyttaris; George C Tsokos
Journal:  J Immunol       Date:  2008-09-01       Impact factor: 5.422
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