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Literature DB >> 11970889

Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity.

Abstract

Indirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that complicates obesity and results in the metabolic syndrome. In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphorylation of Jak2.

Entities: Disease Gene

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Year: 2002 PMID： 11970889 DOI： 10.1016/s1534-5807(02)00158-2

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

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Cited

20 in total

1. H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.

Authors: Navasona Krishnan; Cexiong Fu; Darryl J Pappin; Nicholas K Tonks
Journal: Sci Signal Date: 2011-12-13 Impact factor: 8.192

2. Ghrelin induces leptin resistance by activation of suppressor of cytokine signaling 3 expression in male rats: implications in satiety regulation.

Authors: Andrea Heldsinger; Gintautas Grabauskas; Xiaoyin Wu; ShiYi Zhou; Yuanxu Lu; Il Song; Chung Owyang
Journal: Endocrinology Date: 2014-07-25 Impact factor: 4.736

10. Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling.

Authors: Toshiyuki Fukada; Nicholas K Tonks
Journal: EMBO J Date: 2003-02-03 Impact factor: 11.598

Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity.

1. H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.

2. Ghrelin induces leptin resistance by activation of suppressor of cytokine signaling 3 expression in male rats: implications in satiety regulation.

3. Induction of leptin resistance by activation of cAMP-Epac signaling.

4. Pre- and postnatal calorie restriction perturbs early hypothalamic neuropeptide and energy balance.

Review 5. Central nervous control of energy and glucose balance: focus on the central melanocortin system.

Review 6. Protein tyrosine phosphatase 1B: a novel molecular target for retinal degenerative diseases.

7. Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase.

8. Leptin signaling: A key pathway in immune responses.

9. Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions.

10. Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling.